Jalali Mir Mohammad, Dalili Setila, Koohmanaee Shahin, Rad Samira
Department of Otolaryngology, Otorhinolaryngology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Pediatric Endocrinology & Metabolism, Pediatrics Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Int Arch Otorhinolaryngol. 2023 Aug 4;27(3):e393-e399. doi: 10.1055/s-0041-1742241. eCollection 2023 Jul.
Metabolic syndrome (MetS) and its associated components were reported as a possible cause of inner ear dysfunction. However, research about the influence of cardiovascular risk factors on hearing thresholds are conducted mainly in adult patients. The aim of the present study was to investigate auditory function in adolescents with MetS compared with healthy controls. One hundred adolescents with metabolic syndrome and 200 sex- and age-matched controls were recruited from a university pediatric endocrine clinic from May 2018 to July 2020. Hearing loss was defined as hearing level ≥ 15 dB at speech frequency (SFHL) or high frequency (HFHL) in one or both ears. A multivariable conditional logistic regression analysis examined the correlation between MetS components and several important demographic characteristics, and hearing loss. A total of 165 (55.0%) boys and 135 (45.0%) girls participated in this study. The rates of SFHL and HFHL in adolescents with MetS were 32.0% and 51.0%, respectively. Those values for controls were 5.0% and 15.5%, respectively. The regression analysis showed high triglycerides as a significant predictor for SFHL (odds ratio 10.87; 95% confidence interval: 1.98, 59.74). Neither predictor of interest was significant for HFHL. Hypertriglyceridemia may be an important factor in the pathogenesis of SFHL. However, the strength of the association was not significant with a wide confidence interval. Also, we were unable to find an association between predictors and HFHL with the current sample size. Larger and prospective studies are recommended.
代谢综合征（MetS）及其相关组成部分被报道为内耳功能障碍的可能原因。然而，关于心血管危险因素对听力阈值影响的研究主要在成年患者中进行。
本研究的目的是调查患有代谢综合征的青少年与健康对照组相比的听觉功能。
2018年5月至2020年7月，从一家大学儿科内分泌诊所招募了100名患有代谢综合征的青少年和200名性别及年龄匹配的对照组。听力损失定义为一只或两只耳朵在言语频率（SFHL）或高频（HFHL）时听力水平≥15 dB。多变量条件逻辑回归分析检查了代谢综合征组成部分与几个重要人口统计学特征以及听力损失之间的相关性。
共有165名（55.0%）男孩和135名（45.0%）女孩参与了本研究。患有代谢综合征的青少年中SFHL和HFHL的发生率分别为32.0%和51.0%。对照组的这些值分别为5.0%和15.5%。回归分析显示高甘油三酯是SFHL的显著预测因子（优势比10.87；95%置信区间：1.98，59.74）。对于HFHL，所关注的预测因子均不显著。
高甘油三酯血症可能是SFHL发病机制中的一个重要因素。然而，关联强度在较宽的置信区间内并不显著。此外，根据当前样本量，我们未能发现预测因子与HFHL之间的关联。建议进行更大规模的前瞻性研究。
