Heshmat Ramin, Hemati Zeinab, Qorbani Mostafa, Nabizadeh Asl Laleh, Motlagh Mohammad Esmaeil, Ziaodini Hasan, Taheri Majzoubeh, Ahadi Zeinab, Shafiee Gita, Aminaei Tahereh, Hatami Hooman, Kelishadi Roya
Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
J Cardiovasc Thorac Res. 2018;10(4):214-220. doi: 10.15171/jcvtr.2018.37. Epub 2018 Dec 5.
Metabolic syndrome (MetS) is one of the common metabolic disorders seen in children and adolescents. This study aims to assess the rate of the MetS and its associated factors in a nationally-representative sample of Iranian pediatric age groups. This nationwide cross- sectional study was designed in 2015 in 30 provinces of Iran. Participants consisted of 4,200 school students, aged 7-18 years, studied in a national school-based surveillance program (CASPIAN-V). Physical examination and laboratory tests were performed using standard protocols. Blood samples were drawn from 3834 students for biochemical tests. The participation rate for blood sampling was 91.5%. MetS was significantly more prevalent among students in urban than in rural areas (5.7% vs. 4.8%, value < 0.01). MetS was more prevalent in students with obese parents than in those with non-obese parents (6.4% vs. 4.5%, value < 0.05). Significant association existed between moderate level of healthy nutritional behaviors and MetS after controlling for potential confounders (odds ratio [OR]: 0.62, 95% CI: 0.40-0.98). Students with high unhealthy nutritional behaviors showed an increased risk of MetS in crude (OR: 1.6, 95% CI: 1.05-2.44) and adjusted model (OR: 1.65, 95% CI: 1.05-2.63). High rate of MetS and associated risk factors was observed in Iranian pediatric age groups, with higher rates among boys. These findings provide useful information for effective preventive strategies based on diet, exercise, and lifestyle modification rather than therapeutic modalities.
代谢综合征（MetS）是儿童和青少年中常见的代谢紊乱疾病之一。本研究旨在评估伊朗全国代表性儿科年龄组样本中代谢综合征的发生率及其相关因素。这项全国性横断面研究于2015年在伊朗的30个省份开展。参与者包括4200名7至18岁的在校学生，他们参与了一项全国性的学校监测项目（CASPIAN-V）。采用标准方案进行体格检查和实验室检测。从3834名学生中采集血样进行生化检测。采血参与率为91.5%。代谢综合征在城市学生中的患病率显著高于农村地区（5.7%对4.8%，P值<0.01）。父母肥胖的学生比父母不肥胖的学生中代谢综合征更为普遍（6.4%对4.5%，P值<0.05）。在控制潜在混杂因素后，适度的健康营养行为与代谢综合征之间存在显著关联（优势比[OR]：0.62，95%置信区间：0.40-0.98）。具有高度不健康营养行为的学生在粗模型（OR：1.6，95%置信区间：1.05-2.44）和调整模型（OR：1.65，95%置信区间：1.05-2.63）中患代谢综合征的风险增加。在伊朗儿科年龄组中观察到代谢综合征及其相关风险因素的高发生率，男孩中的发生率更高。这些发现为基于饮食、运动和生活方式改变而非治疗方式的有效预防策略提供了有用信息。
