Department of Flow Cytometry, Cytek Biosciences, Fremont, CA, United States.
MassBiologics of the University of Massachusetts Medical School, Boston, MA, United States.
Front Immunol. 2023 Jul 26;14:1188864. doi: 10.3389/fimmu.2023.1188864. eCollection 2023.
Speck assembly is the hallmark of NLRP3 inflammasome activation. The 1µm structure comprising of NLRP3 and ASC is the first observable phenotype of NLRP3 activation. While the common consensus is that the specks are the site of inflammasome activity, no direct experimental evidence exists to support this notion. In these 22 years, since the inflammasome discovery, several research studies have been published which directly or indirectly support or refute the idea of speck being the inflammasome. This review compiles the data from two decades of research to answer a long-standing question: "What are NLRP3-ASC specks?"
斑点形成是 NLRP3 炎性小体激活的标志。包含 NLRP3 和 ASC 的 1µm 结构是 NLRP3 激活的第一个可观察表型。尽管普遍共识认为斑点是炎性小体活性的部位，但没有直接的实验证据支持这一观点。自炎性小体发现以来的 22 年中，已经发表了几项研究，这些研究直接或间接地支持或反驳了斑点是炎性小体的观点。这篇综述汇集了过去二十年的研究数据，旨在回答一个长期存在的问题：“NLRP3-ASC 斑点是什么？”
