Kennett G A, Chaouloff F, Marcou M, Curzon G
Brain Res. 1986 Sep 24;382(2):416-21. doi: 10.1016/0006-8993(86)91355-7.
A single 2-h restraint stress reduces locomotion and increases defaecation of male rats placed in an open field 24 h later. After daily 2-h restraints for 5 days these effects were no longer observed. This adaptation was associated with enhanced sensitivity to the serotonin agonist 5-methoxy-N,N-dimethyltryptamine. Female rats were less affected by a single restraint but failed to adapt to the repeated stress procedure and did not exhibit enhanced sensitivity to 5-methoxy-N,N-dimethyltryptamine. Furthermore, females but not males killed 24 h after the final restraint period had decreased brain regional 5-hydroxyindoleacetic acid concentrations particularly in the frontal cortex. No sex differences in hypothalamic and striatal dopamine metabolism were observed. The above differences between male and female rats were unaffected by adult gonadectomy. Similar differences could be involved in the higher incidence of depressive illness in women.
单次2小时的束缚应激会降低雄性大鼠的活动能力，并增加其在24小时后置于旷场中的排便量。在每日进行2小时束缚，持续5天后，这些效应不再出现。这种适应性变化与对血清素激动剂5-甲氧基-N,N-二甲基色胺的敏感性增强有关。雌性大鼠受单次束缚的影响较小，但无法适应重复应激程序，且对5-甲氧基-N,N-二甲基色胺未表现出敏感性增强。此外，在最后一次束缚期后24小时处死的雌性大鼠而非雄性大鼠，其脑区5-羟吲哚乙酸浓度降低，尤其是在额叶皮质。未观察到下丘脑和纹状体多巴胺代谢的性别差异。成年去势对雄性和雌性大鼠之间的上述差异没有影响。类似的差异可能与女性抑郁症发病率较高有关。
