South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, China.
College of International Studies, Shenzhen University, Shenzhen, China.
J Biophotonics. 2023 Nov;16(11):e202300151. doi: 10.1002/jbio.202300151. Epub 2023 Aug 19.
Diffuse correlation spectroscopy (DCS) was used to measure resting-state cerebral blood flow (CBF) in temporal lobes of children with autism spectrum disorder (ASD) and typically developing (TD) children. Twenty-two children with ASD and 34 age-matched TD children were recruited to participate in the experiment. DCS signals were recorded with 3 long source-detector (SD) channels (SD distance = 22.0 mm) and 1 short SD channel (SD distance = 10.5 mm) from each side of the temporal lobe. Significant difference in CBF between left and right hemispheres was observed in ASD group, but not in TD group. With the degree of CBF lateralization as a discrimination feature, a leave-one-out ROC curve was plotted with the area-under-curve (AUC) value of 0.731 ± 0.010, indicating children with ASD could be discriminated from TD children. This suggested CBF lateralization in temporal lobes measured with DCS might serve as a discriminative feature for ASD.
漫射相关光谱（DCS）用于测量自闭症谱系障碍（ASD）儿童和典型发育（TD）儿童静息状态下的大脑血流（CBF）。招募了 22 名 ASD 儿童和 34 名年龄匹配的 TD 儿童参加实验。从颞叶两侧的 3 个长源-探测器（SD）通道（SD 距离= 22.0mm）和 1 个短 SD 通道（SD 距离= 10.5mm）记录 DCS 信号。在 ASD 组中观察到 CBF 在左右半球之间存在显著差异，但在 TD 组中没有观察到。以 CBF 侧化程度作为鉴别特征，绘制了留一法 ROC 曲线，曲线下面积（AUC）值为 0.731±0.010，表明可以将 ASD 儿童与 TD 儿童区分开来。这表明 DCS 测量的颞叶 CBF 侧化可能是 ASD 的一个鉴别特征。
