Harboe S, Levang O W, Hysing E S
Acta Anaesthesiol Scand. 1979 Apr;23(2):165-76. doi: 10.1111/j.1399-6576.1979.tb01437.x.
It has previously been shown that patients who have undergone mitral valve replacement (MVR) tolerate a positive end expiratory pressure (PEEP) of 1.0 kPa better than patients who have had aortic valve replacement (AVR). the difference was explained by the fact that the mitral patients had pre-existing pulmonary vascular disease. In the present study the effect of PEEP up to 2.0 kPa is investigated in three types of operations: aortocoronary bypass graft (ACBG), mitral valve replacement, and aortic valve replacement; there were five patients in each group. We found that our mitral patients tolerated PEEP better than the two other groups, and that tolerance was not correlated to a higher pulmonary vascular resistance, but rather to a higher level of pulmonary capillary wedge pressure. The influence of PEEP varies in different types of patients and the effect is still difficult to predict.
先前的研究表明,接受二尖瓣置换术(MVR)的患者比接受主动脉瓣置换术(AVR)的患者更能耐受1.0 kPa的呼气末正压(PEEP)。这种差异的原因是二尖瓣置换术患者术前就存在肺血管疾病。在本研究中,对三种手术类型(主动脉冠状动脉搭桥术(ACBG)、二尖瓣置换术和主动脉瓣置换术)患者在高达2.0 kPa的PEEP作用下的效果进行了研究;每组有5名患者。我们发现,二尖瓣置换术患者比其他两组患者更能耐受PEEP,且这种耐受性与较高的肺血管阻力无关,而是与较高的肺毛细血管楔压水平有关。PEEP对不同类型患者的影响各不相同,其效果仍然难以预测。