Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, US.
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine, Lebanon, NH, US.
Am J Clin Pathol. 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100.
TRPS1 is a new, sensitive marker for breast carcinoma (BC). Salivary glands and breasts are both exocrine glands; thus, their tumors may share similar morphology and immunophenotype. Among salivary gland-type BC, TRPS1 is reported to be positive in secretory carcinomas (SCs) but negative in acinic cell carcinomas (AciCCs) and most adenoid cystic carcinomas (AdCCs). A subset of salivary duct carcinomas (SDCs) is positive for TRPS1. Herein, we investigate TRPS1 immunohistochemical expression in salivary gland tumors (SGTs).
A retrospective search yielded 110 SGTs (97 primary and 13 metastatic). TRPS1 immunohistochemistry was scored as negative, low positive, intermediate positive, or strongly positive.
TRPS1 was expressed in 78% (14/18) of pleomorphic adenoma (PA) cases but negative/low positive in all Warthin tumors (6/6 [100%]). In basal cell adenoma (BCA), TRPS1 expression was intermediate to strong (13/14 [92%]) in the stromal cells, whereas ductal or basal cells showed low expression. TRPS1 expression varied in malignant SGTs, with intermediate to strong staining in 100% (15/15) of AdCCs, 100% (5/5) of basal cell adenocarcinoma, 100% (3/3) of intraductal carcinoma, 89% (8/9) of polymorphous adenocarcinoma, and 89% (7/8) of SDCs; negative/low positive expression was observed in 100% (3/3) of SCs, 89% (8/9) of AciCCs, and 50% (3/3) of mucoepidermoid carcinomas. In addition, strong and intermediate TRPS1 expression was observed in metastatic SGT to the lungs, lymph nodes, and soft tissue.
Overall, TRPS1 is strongly expressed in PA as well as malignant and metastatic SGT. In addition, TRPS1 is positive in stromal cells of BCA but negative or low positive in ductal and basal cells.
TRPS1 是一种新的、敏感的乳腺癌标志物。唾液腺和乳腺均为外分泌腺；因此，它们的肿瘤可能具有相似的形态和免疫表型。在唾液腺型乳腺癌中，TRPS1 在分泌性癌（SCs）中呈阳性，但在腺样囊性癌（AciCCs）和大多数腺泡细胞癌（AdCCs）中呈阴性。唾液导管癌（SDC）的一部分为 TRPS1 阳性。在此，我们研究了 TRPS1 在唾液腺肿瘤（SGTs）中的免疫组织化学表达。
回顾性搜索得到 110 例 SGTs（97 例原发和 13 例转移）。TRPS1 免疫组化评分阴性、弱阳性、中等阳性或强阳性。
多形性腺瘤（PA）病例中 TRPS1 的表达率为 78%（14/18），而所有沃辛瘤（Warthin tumor，6/6 [100%]）均为阴性/弱阳性。在基底细胞腺瘤（BCA）中，间质细胞中 TRPS1 表达为中等至强阳性（13/14 [92%]），而导管或基底细胞表达低水平。恶性 SGTs 中 TRPS1 表达不同，其中 AdCCs 的强阳性表达率为 100%（15/15），基底细胞腺癌为 100%（5/5），导管内癌为 100%（3/3），多形性腺癌为 89%（8/9），SDC 为 89%（7/8）；SCs 的阴性/弱阳性表达率为 100%（3/3），AciCCs 为 89%（8/9），黏液表皮样癌为 50%（3/3）。此外，肺部、淋巴结和软组织转移的 SGT 中可见强阳性和中等强度的 TRPS1 表达。
总体而言，TRPS1 在 PA 以及恶性和转移性 SGT 中表达较强。此外，TRPS1 在 BCA 的间质细胞中呈阳性，但在导管和基底细胞中呈阴性或弱阳性。
