Itoh S, Katsuura G
Can J Physiol Pharmacol. 1986 Jun;64(6):745-7. doi: 10.1139/y86-125.
Cholecystokinin octapeptide (CCK-8) was administered intracerebroventricularly (icv) or subcutaneously (sc) into subdiaphragmatically vagotomized and sham-operated rats, and the behavioral effects were quantified by an open-field test. Intracerebroventricularly injection of CCK-8 decreased locomotion and rearing to the same extent in both vagotomized and sham-operated rats, while sc injection produced behavioral changes only in sham-operated rats but not in vagotomized ones. The results indicate that CCK-8 affects both central and peripheral receptors, and the vagal nerve may be the major pathway causing behavioral effects from the visceral organs to the brain.
将八肽胆囊收缩素（CCK - 8）经脑室注射（icv）或皮下注射（sc）给膈下迷走神经切断和假手术的大鼠，并通过旷场试验对行为效应进行量化。脑室注射CCK - 8在迷走神经切断和假手术的大鼠中均使运动和竖毛减少到相同程度，而皮下注射仅在假手术大鼠中产生行为变化，在迷走神经切断的大鼠中未产生变化。结果表明，CCK - 8影响中枢和外周受体，迷走神经可能是导致从内脏器官到大脑产生行为效应的主要途径。
