Wang Li, Fan Lu, Filppula Anne M, Wang Yu, Bian Feika, Shang Luoran, Zhang Hongbo
Joint Centre of Translational Medicine, Wenzhou Key Laboratory of Interdiscipline and Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Pharmaceutical Sciences Laboratory, Åbo Akademi University, Turku, 20520, Finland.
Bioact Mater. 2025 Jan 7;46:494-502. doi: 10.1016/j.bioactmat.2025.01.002. eCollection 2025 Apr.
Hydrogel-based patches have demonstrated their values in diabetic wounds repair, particularly those intelligent dressings with continuous repair promoting and monitoring capabilities. Here, we propose a type of dual physiological responsive structural color particles for wound repair. The particles are composed of a hyaluronic acid methacryloyl (HAMA)-sodium alginate (Alg) inverse opal scaffold, filled with oxidized dextran (ODex)/quaternized chitosan (QCS) hydrogel. The photo-polymerized HAMA and ionically cross-linked Ca-Alg constitute to the dual-network hydrogel with stable structural color. Furthermore, the ODex/QCS hydrogel, combined with glucose oxidase (GOX), exhibits pH/glucose dual responsiveness. Moreover, antimmicrobial peptide (AMP) plus vascular endothelial growth factor (VEGF) are comprised within the GOX-doped ODex/QCS hydrogel. In the high-glucose wound environment, GOX catalyzes glucose to generate acidic products, triggering rapid release of AMP and VEGF. Importantly, this process also leads to structural color changes of the particles, offering significant potential for wound monitoring. It has been demonstrated that such particles greatly promote the healing progress of diabetic wound . These results indicate that the present dual responsive particles would find valuable applications in diabetic wounds repair and the associated areas.
水凝胶基贴片已在糖尿病伤口修复中展现出其价值，尤其是那些具有持续促进修复和监测能力的智能敷料。在此，我们提出一种用于伤口修复的双生理响应结构色颗粒。这些颗粒由甲基丙烯酰化透明质酸（HAMA）-海藻酸钠（Alg）反蛋白石支架组成，内部填充有氧化葡聚糖（ODex）/季铵化壳聚糖（QCS）水凝胶。光聚合的HAMA和离子交联的Ca-Alg构成具有稳定结构色的双网络水凝胶。此外，ODex/QCS水凝胶与葡萄糖氧化酶（GOX）结合，表现出pH/葡萄糖双重响应性。而且，抗菌肽（AMP）加血管内皮生长因子（VEGF）包含在掺杂GOX的ODex/QCS水凝胶中。在高糖伤口环境中，GOX催化葡萄糖生成酸性产物，触发AMP和VEGF的快速释放。重要的是，这一过程还会导致颗粒的结构色变化，为伤口监测提供了巨大潜力。已证明此类颗粒极大地促进了糖尿病伤口的愈合进程。这些结果表明，当前的双响应颗粒在糖尿病伤口修复及相关领域将有重要应用价值。
