Freiermuth Caroline E, Ancona Rachel M, Brown Jennifer L, Punches Brittany E, Ryan Shawn A, Ingram Tim, Lyons Michael S
Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
Center for Addiction Research, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
PLoS One. 2023 Aug 11;18(8):e0289959. doi: 10.1371/journal.pone.0289959. eCollection 2023.
To report per-capita distribution of take-home naloxone to lay bystanders and evaluate changes in opioid overdose mortality in the county over time.
Hamilton County Public Health in southwestern Ohio led the program from Oct 2017-Dec 2019. Analyses included all cartons distributed within Hamilton County or in surrounding counties to people who reported a home address within Hamilton County. Per capita distribution was estimated using publicly available census data. Opioid overdose mortality was compared between the period before (Oct 2015-Sep 2017) and during (Oct 2017-Sep 2019) the program.
A total of 10,416 cartons were included for analyses, with a total per capita distribution of 1,275 cartons per 100,000 county residents (average annual rate of 588/100,000). Median monthly opioid overdose mortality in the two years before (28 persons, 95% CI 25-31) and during (26, 95% CI 23-28) the program did not differ significantly.
Massive and rapid naloxone distribution to lay bystanders is feasible. Even large-scale take-home naloxone distribution may not substantially reduce opioid overdose mortality rates.
报告向非专业旁观者发放的可带回家使用的纳洛酮的人均发放量，并评估该县阿片类药物过量死亡率随时间的变化。
俄亥俄州西南部的汉密尔顿县公共卫生部门在2017年10月至2019年12月期间主导了该项目。分析纳入了在汉密尔顿县或周边县分发给报告家庭住址在汉密尔顿县的人的所有纸盒包装纳洛酮。人均发放量使用公开的人口普查数据进行估算。对项目实施前（2015年10月至2017年9月）和实施期间（2017年10月至2019年9月）的阿片类药物过量死亡率进行了比较。
共有10416个纸盒包装纳洛酮纳入分析，人均发放量为每10万县居民1275盒（年平均发放率为588/10万）。项目实施前两年（28人，95%CI 25 - 31）和实施期间（26人，95%CI 23 - 28）的阿片类药物过量月死亡率中位数无显著差异。
向非专业旁观者大规模快速发放纳洛酮是可行的。即使是大规模发放可带回家使用的纳洛酮，也可能不会显著降低阿片类药物过量死亡率。
