Olson G R, Miller L D
Can J Vet Res. 1986 Apr;50(2):245-50.
Pseudorabies virus was inoculated by various routes into dogs to determine the relationship of pseudorabies virus to the development of heart lesions. Electrocardiograms and serum samples for lactate dehydrogenase isoenzymes were taken twice daily. Transitory and persistent arrhythmias were a consistent finding. Heart lesions were noted within each of the inoculated groups. These changes varied from severe multifocal areas of hemorrhage and myocardial degeneration to small zones of myolysis. A ganglioneuritis of the stellate ganglia and autonomic ganglia within the heart were also consistent findings. Herpes-like viral particles were found by electron microscopy in various autonomic ganglia and in myocardial endothelial cells. No viral particles were found in myocardial cells. Significant increases in lactate dehydrogenase-1 were noted. It was concluded that fatal arrhythmias resulted from pseudorabies virus infections in the dog after the occurrence of myocardial and ganglionic lesions.
通过多种途径将伪狂犬病病毒接种到犬体内，以确定伪狂犬病病毒与心脏病变发展之间的关系。每天采集两次心电图和用于乳酸脱氢酶同工酶检测的血清样本。短暂性和持续性心律失常是一个持续出现的结果。在每个接种组中均发现了心脏病变。这些变化从严重的多灶性出血和心肌变性到小范围的肌溶解不等。心脏内星状神经节和自主神经节的神经节神经炎也是持续出现的结果。通过电子显微镜在各种自主神经节和心肌内皮细胞中发现了疱疹样病毒颗粒。在心肌细胞中未发现病毒颗粒。乳酸脱氢酶-1显著升高。得出的结论是，在心肌和神经节病变发生后，犬的伪狂犬病病毒感染导致了致命性心律失常。
