Meunier P C, Cooper B J, Appel M J, Slauson D O
Vet Pathol. 1984 Sep;21(5):509-15. doi: 10.1177/030098588402100510.
Myocarditis was produced in seronegative five-day-old pups by oral and by intraperitoneal inoculation of canine parvovirus. The disease was subclinical. Histologic lesions were compatible with, but less extensive than, those seen in naturally occurring canine parvoviral myocarditis. In pups necropsied 23 days after inoculation, scattered cardiac myocytes contained intranuclear inclusion bodies, and virus-infected myocytes were demonstrated by immunofluorescence. Degeneration and loss of cardiac myocytes usually was not associated with a cellular infiltrate. At 51 days after inoculation, the myocardium contained an extensive lymphocytic infiltrate which was sometimes associated with fragmented myocytes, and was often contiguous with areas of interstitial fibrosis. At 108 days after inoculation, inflammatory lesions had regressed, and there were multifocal areas of myocardial fibrosis.
通过口服和腹腔接种犬细小病毒，在血清阴性的5日龄幼犬中诱发心肌炎。该疾病为亚临床型。组织学病变与自然发生的犬细小病毒性心肌炎所见病变相符，但程度较轻。在接种后23天进行尸检的幼犬中，散在的心肌细胞含有核内包涵体，免疫荧光显示存在病毒感染的心肌细胞。心肌细胞的变性和丢失通常与细胞浸润无关。接种后51天，心肌有广泛的淋巴细胞浸润，有时与破碎的心肌细胞有关，且常与间质纤维化区域相邻。接种后108天，炎症病变消退，出现多灶性心肌纤维化。
