Batta Rita, Njoum Yumna, Deek Rahmeh, Awad Fadi, Bakri Izzeddin A, Maree Mohammed
General surgery department, Al-Makassed Hospital, Jerusalem, Palestine.
Faculty of Medicine, Al-Quds University, Jerusalem, Palestine.
Int J Surg Case Rep. 2023 Aug;109:108625. doi: 10.1016/j.ijscr.2023.108625. Epub 2023 Aug 5.
Sternal metastasis of follicular thyroid cancer (FTC) is rare as only 15 cases have been reported in the literature in which most cases of sternal metastasis occurs form breast and lung cancer. Surgical excision of the metastatic mass provides the best option due to its curative benefit, symptomatic palliation, and better response to radioactive iodine.
Herein, we present a 77-year-old female patient with a known history of follicular thyroid carcinoma with isolated sternal metastasis treated with total thyroidectomy and en-bloc resection of the metastasis, followed by chest wall reconstruction using pectoralis major muscle flap.
Surgical excision of metastatic FTC to sternum with chest wall reconstruction was seldom reported as the treatment of choice. In most cases in the literature, mesh was used. However, in our patient mesh was not used taking into consideration the drastic consequences of wound infection and the possible need for mesh retrieval in such a dangerous area in proximity to the mediastinum. We believe that myo-adipo-facial flap is a more reasonable and safe option.
In patients with FTC, large tumors and bone metastases are factors that indicate poor prognostic factors, both of which were present in our patient. However, surgical excision provides hope for a better quality of life as it enhances subsequent Radioactive Iodine (RAI) therapy.
滤泡状甲状腺癌(FTC)的胸骨转移罕见,文献中仅报道了15例,其中大多数胸骨转移病例源自乳腺癌和肺癌。由于手术切除转移瘤具有治愈效果、缓解症状以及对放射性碘反应更佳等益处,因此是最佳选择。
在此,我们报告一名77岁女性患者,其有滤泡状甲状腺癌病史,伴有孤立性胸骨转移,接受了全甲状腺切除术及转移瘤整块切除术,随后采用胸大肌肌瓣进行胸壁重建。
手术切除转移至胸骨的FTC并进行胸壁重建作为首选治疗方法鲜有报道。文献中的大多数病例使用了补片。然而,考虑到伤口感染的严重后果以及在如此靠近纵隔的危险区域可能需要取出补片,我们的患者未使用补片。我们认为肌-脂肪-筋膜瓣是更合理且安全的选择。
在FTC患者中,肿瘤体积大及骨转移是提示预后不良的因素,我们的患者这两个因素均存在。然而,手术切除为提高生活质量带来了希望,因为它增强了后续的放射性碘(RAI)治疗。