Cancer Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China; International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute/Hospital, Second Military Medical University, Shanghai, 200438, China; National Center for Liver Cancer, Second Military Medical University, Shanghai, 201805, China.
International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute/Hospital, Second Military Medical University, Shanghai, 200438, China; National Center for Liver Cancer, Second Military Medical University, Shanghai, 201805, China.
Cancer Lett. 2023 Sep 1;571:216348. doi: 10.1016/j.canlet.2023.216348. Epub 2023 Aug 9.
Copper is a necessary cofactor vital for maintaining biological functions, as well as participating in the development of cancer. A plethora of studies have demonstrated that copper is a double-edged sword, presenting both benefits and detriments to tumors. The liver is a metabolically active organ, and an imbalance of copper homeostasis can result in deleterious consequences to the liver. Hepatocellular carcinoma (HCC), the most common primary liver cancer, is a highly aggressive malignancy with limited viable therapeutic options. As research advances, the focus has shifted towards the relationships between copper and HCC. Innovatively, cuproplasia and cuproptosis have been proposed to depict copper-related cellular growth and death, providing new insights for HCC treatment. By summarizing the constantly elucidated molecular connections, this review discusses the mechanisms of copper in the pathogenesis, progression, and potential therapeutics of HCC. Additionally, we aim to tentatively provide a theoretical foundation and gospel for HCC patients.
铜是维持生物功能所必需的辅助因子，也是癌症发展的参与者。大量研究表明，铜是一把双刃剑，对肿瘤既有好处也有危害。肝脏是一个代谢活跃的器官，铜动态平衡的失衡会对肝脏造成有害的后果。肝细胞癌（HCC）是最常见的原发性肝癌，是一种侵袭性很强的恶性肿瘤，治疗选择有限。随着研究的进展，人们的注意力转向了铜与 HCC 之间的关系。创新性地提出了铜质形成和铜死亡来描述与铜相关的细胞生长和死亡，为 HCC 的治疗提供了新的见解。通过总结不断阐明的分子联系，本综述讨论了铜在 HCC 的发病机制、进展和潜在治疗中的作用机制。此外，我们旨在为 HCC 患者提供一个理论基础和福音。
