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糖尿崩漏:1 型糖尿病成人中的一种危险趋势。

Diabulimia: A Risky Trend Among Adults with Type 1 Diabetes Mellitus.

机构信息

Division of Primary Care and Population Health, Stanford University School of Medicine, Stanford, California; Department of Internal Medicine, Kaiser Permanente Mountain View Medical Offices, Mountain View, California.

Department of Clinical Sciences, Touro University California College of Pharmacy, Vallejo, California.

出版信息

Endocr Pract. 2023 Nov;29(11):849-854. doi: 10.1016/j.eprac.2023.08.001. Epub 2023 Aug 9.

Abstract

OBJECTIVE

Poor adherence leads to worse glycemic control and increased complications in patients with type 1 diabetes mellitus (T1DM). Diabulimia characterizes patients with T1DM who skip or use less insulin for weight loss purposes. The study objectives were to determine: (1) the prevalence of diabulimia among adult patients with T1DM, (2) compare patients with and without diabulimia, and (3) identify factors that may place individuals at higher risk of diabulimia.

METHODS

A 40-item, web-based survey was administered to 21 T1DM discussion boards, Listservs, and social media outlets. The survey assessed demographics, diabetes management, psychiatric diagnoses, and screened for diabulimia. Individuals who reported intentionally skipping or using less insulin than directed for the purpose of weight loss or to prevent weight gain in the past 12 months were classified as having diabulimia.

RESULTS

Of the 225 participants who completed the survey, 8.9% had diabulimia. Patients with diabulimia had elevated hemoglobin A1C (A1C) levels (8.4% vs 6.9%; P = .014), higher rates of a diabetes-related emergency department visits or hospitalization (30.0% vs 13.2%; P = .042), and higher rates of a major depressive disorder diagnosis (40.0% vs 11.5%; P < .001) than patients without diabulimia. Factors associated with diabulimia included high A1C levels (odds ratio, 1.43; 95% CI [1.08-1.91]; P = .014) and a major depressive disorder diagnosis (odds ratio, 4.87; 95% CI [1.31-18.22]; P = .018).

CONCLUSION

Approximately 1 in 11 adult patients with T1DM screened positive for diabulimia. Higher A1C levels and a diagnosis of major depressive disorder were associated with diabulimia.

摘要

目的

1 型糖尿病(T1DM)患者的依从性差会导致血糖控制更差,并增加并发症。患有 T1DM 的患者会出现故意减少或不使用胰岛素来减轻体重的情况,即“diabulimia”。本研究旨在:(1)确定 T1DM 成年患者中“diabulimia”的流行率,(2)比较患有和不患有“diabulimia”的患者,以及(3)确定可能使个体处于更高“diabulimia”风险的因素。

方法

我们向 21 个 T1DM 讨论版块、列表服务器和社交媒体渠道发布了一个包含 40 个问题的在线调查。该调查评估了人口统计学特征、糖尿病管理、精神科诊断,并筛查了“diabulimia”。过去 12 个月内,为了减轻体重或防止体重增加而故意减少或不按规定使用胰岛素的个体被归类为患有“diabulimia”。

结果

在完成调查的 225 名参与者中,8.9%患有“diabulimia”。患有“diabulimia”的患者糖化血红蛋白(A1C)水平升高(8.4% vs 6.9%;P=0.014),因糖尿病急诊就诊或住院的比例更高(30.0% vs 13.2%;P=0.042),且重度抑郁障碍的诊断率更高(40.0% vs 11.5%;P<.001)。与无“diabulimia”的患者相比,与“diabulimia”相关的因素包括高 A1C 水平(优势比,1.43;95%置信区间 [1.08-1.91];P=0.014)和重度抑郁障碍的诊断(优势比,4.87;95%置信区间 [1.31-18.22];P=0.018)。

结论

约 11%的成年 T1DM 患者筛查出患有“diabulimia”。更高的 A1C 水平和重度抑郁障碍的诊断与“diabulimia”相关。

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