State Key Laboratory of Food Nutrition & Safety, Tianjin University of Science and Technology, Tianjin, P. R. China.
Key Laboratory of Industrial Fermentation Microbiology, (Ministry of Education), Tianjin University of Science and Technology, Tianjin, P. R. China.
Small. 2023 Nov;19(48):e2303591. doi: 10.1002/smll.202303591. Epub 2023 Aug 11.
An asymmetric wound dressing acts as a skin-like structure serves as a protective barrier between a wound and its surroundings. It allows for the absorption of tissue fluids and the release of active substances at the wound site, thus speeding up the healing process. However, the production of such wound dressings requires the acquisition of specialized tools, expensive polymers, and solvents that contain harmful byproducts. In this study, an asymmetric bacterial cellulose (ABC) wound dressing using starch as a porogen has been developed. By incorporating silver-metal organic frameworks (Ag-MOF) and curcumin into the ABC membrane, the wound dressing gains antioxidant, reactive oxygen species (ROS) scavenging, and anti-bacterial activities. Compared to BC-based wound dressings, this dressing promotes efficient dissolution and controlled release of curcumin and silver ions. In a full-thickness skin defect model, wound dressing not only inhibits the growth of bacteria on infected wounds but also regulates the release of curcumin to reduce inflammation and promote the production of epithelium, blood vessels, and collagen. Consequently, this dressing provides superior wound treatment compared to BC-based dressing.
一种不对称创面敷料充当类似皮肤的结构，作为创面与其周围环境之间的保护屏障。它允许组织液的吸收和活性物质在创面部位的释放，从而加速愈合过程。然而，此类创面敷料的生产需要获得专门的工具、昂贵的聚合物和含有有害副产物的溶剂。在这项研究中，开发了一种使用淀粉作为致孔剂的不对称细菌纤维素（ABC）创面敷料。通过将银-金属有机骨架（Ag-MOF）和姜黄素掺入 ABC 膜中，创面敷料获得了抗氧化、活性氧（ROS）清除和抗菌活性。与基于 BC 的创面敷料相比，这种敷料促进了姜黄素和银离子的有效溶解和控制释放。在全层皮肤缺损模型中，创面敷料不仅抑制了感染创面细菌的生长，而且还调节了姜黄素的释放，以减轻炎症并促进上皮、血管和胶原蛋白的产生。因此，与基于 BC 的敷料相比，这种敷料提供了更好的创面治疗效果。
