Bukatuka Clemence Futila, Mbituyimana Bricard, Xiao Lin, Qaed Ahmed Abeer Ahmed, Qi Fuyu, Adhikari Manjilla, Shi Zhijun, Yang Guang
Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China.
J Funct Biomater. 2025 Apr 23;16(5):151. doi: 10.3390/jfb16050151.
Rapid hemostasis and wound healing are crucial severe trauma treatment. Natural mechanisms often prove insufficient, spurring research for innovative biomaterials. This review focuses on cellulose-based materials, which are promising due to their absorbency, biocompatibility, and processability. The novelty lies in exploring how these materials promote clotting and tissue regeneration. They operate via extrinsic and intrinsic mechanisms. Extrinsically, they create a matrix at the wound to activate coagulation; intrinsically, they maintain clotting factors. Additionally, they aid healing through physical, chemical, and biological means, such as maintaining moisture, incorporating antimicrobial agents, and stimulating cell activity. The innovative fabrication strategies include material selection and chemical modification. Techniques like oxidation enhance performance. Structural engineering methods like freeze-drying and 3D printing optimize porosity and alignment. Cellulose-based dressings are versatile and effective in various forms. They address different wound needs and show benefits like rapid coagulation and tissue repair. This review also covers challenges and future trends, emphasizing the need to enhance mechanical properties and biodegradability. Further, new technologies offer potential improvements to the nanocomposites. Overall, continued research on cellulose-based dressing is vital, and unlocking their potential could revolutionize wound care, providing suitable solutions for trauma management.
快速止血和伤口愈合是严重创伤治疗的关键。事实证明，自然机制往往并不充分，这促使人们对创新生物材料展开研究。本综述聚焦于纤维素基材料，因其具有吸水性、生物相容性和可加工性而颇具前景。其新颖之处在于探索这些材料如何促进凝血和组织再生。它们通过外在和内在机制发挥作用。从外在方面来看，它们在伤口处形成一个基质以激活凝血；从内在方面来说，它们维持凝血因子。此外，它们还通过物理、化学和生物学手段辅助愈合，例如保持湿润、加入抗菌剂以及刺激细胞活性。创新的制备策略包括材料选择和化学改性。诸如氧化等技术可提高性能。像冷冻干燥和3D打印这样的结构工程方法可优化孔隙率和排列。纤维素基敷料形式多样且效果显著。它们能满足不同的伤口需求，并展现出快速凝血和组织修复等益处。本综述还涵盖了挑战和未来趋势，强调了增强机械性能和生物降解性的必要性。此外，新技术为纳米复合材料带来了潜在的改进。总体而言，对纤维素基敷料持续开展研究至关重要，挖掘其潜力可能会彻底改变伤口护理方式，为创伤管理提供合适的解决方案。
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