Domínguez-Rodríguez Alberto, Avanzas Pablo, Báez-Ferrer Néstor, Abreu-González Pedro, Rodríguez Sergio, Matos-Castro Sebastian, Hernández-Vaquero Daniel
Servicio de Cardiología, Hospital Universitario de Canarias, Ofra S/N La Cuesta, E-38410 Tenerife, Spain.
Facultad de Ciencias de la Salud, Universidad Europea de Canarias, 38300 Tenerife, Spain.
J Clin Med. 2023 Jul 29;12(15):4990. doi: 10.3390/jcm12154990.
The main objective of this study is to determine whether exposure to Saharan dust causes airway inflammation and oxidative stress in patients with stable chronic heart failure (HF) and a left ventricular ejection fraction of less than 40%.
A longitudinal study design is used, involving the inclusion of 40 patients with stable chronic HF and a left ventricular ejection fraction of less than 40%. Four sputum samplings will be taken from each patient, with one sampling taken each week over four consecutive weeks. The sputum samples will be used to analyze the degree of inflammation and oxidative stress. Air quality monitoring stations will be used to analyze the particulate matter (PM) exposure of each patient. The intrusion of desert dust will be identified using meteorological models. There will be 160 scheduled samplings in 40 patients with chronic HF. Mixed regression models will be used to assess the influence of the concentrations of PM (from the episodes of desert dust) upon the airway inflammation and oxidative stress markers.
The results of this study will test the hypothesis that exposure to high concentrations of Saharan dust affects the normal function of the respiratory epithelium due to the imbalance between the production of free radicals and antioxidant enzymes, thus causing increased pulmonary inflammation and oxidative stress in patients with HF that in turn may facilitate decompensations of their background disease condition.
本研究的主要目的是确定暴露于撒哈拉沙尘是否会在稳定的慢性心力衰竭（HF）且左心室射血分数低于40%的患者中引起气道炎症和氧化应激。
采用纵向研究设计，纳入40例稳定的慢性HF且左心室射血分数低于40%的患者。每位患者将采集4次痰液样本，在连续四周内每周采集一次。痰液样本将用于分析炎症和氧化应激程度。空气质量监测站将用于分析每位患者的颗粒物（PM）暴露情况。将使用气象模型识别沙漠沙尘的侵入。40例慢性HF患者将进行160次预定采样。混合回归模型将用于评估PM浓度（来自沙漠沙尘事件）对气道炎症和氧化应激标志物的影响。
本研究结果将检验以下假设：暴露于高浓度的撒哈拉沙尘会由于自由基产生与抗氧化酶之间的失衡而影响呼吸道上皮的正常功能，从而导致HF患者肺部炎症和氧化应激增加，进而可能促使其基础疾病失代偿。
