Guo Kangwen, Xiao Weiliang, Chen Xinggui, Zhao Zhenying, Lin Yuanxiong, Chen Ge
Department of Radiotherapy, Central Hospital of Guangdong Nongken, Zhanjiang, China.
Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Biomed Res Int. 2021 Jul 14;2021:1738932. doi: 10.1155/2021/1738932. eCollection 2021.
Over the past decades, lots of advance have occurred in the prevention, diagnosis, and treatment of head and neck cancer (HNC). However, the contemporaneous incidence and survival trends, on the basis of population-based registry, have not been reported.
The HNC cancer cases were accessed from the Surveillance, Epidemiology, and End Results (SEER) database. The incidence trend was analyzed by joinpoint analysis, with the survival trend being analyzed by period analysis of relative survival rate (RSR) and Kaplan-Meier analyses. Cox regression analysis was performed to identify the prognostic factors for overall survival.
The general incidence trend of HNC increases slightly, with an average annual percentage change of 0.6%, along with five fluctuating segments. The improvement of net survival over the past decades was showed by increasing 60-month RSR, from 54.1% to 56.0% to 60.9% to 66.8%, which was further confirmed by Kaplan-Meier analyses. Moreover, disparities in incidence and survival patterns can be observed in different subgroups.
A fluctuating incidence pattern and an ever-improving survival were observed in HNC over time.
在过去几十年中，头颈癌（HNC）的预防、诊断和治疗取得了许多进展。然而，基于人群登记的同期发病率和生存趋势尚未见报道。
从监测、流行病学和最终结果（SEER）数据库中获取头颈癌病例。采用Joinpoint分析方法分析发病率趋势，采用相对生存率（RSR）的周期分析和Kaplan-Meier分析方法分析生存趋势。进行Cox回归分析以确定总生存的预后因素。
头颈癌的总体发病率趋势略有上升，年均变化率为0.6%，呈现出五个波动阶段。过去几十年净生存率的提高表现为60个月相对生存率从54.1%提高到56.0%，再到60.9%，最后到66.8%，Kaplan-Meier分析进一步证实了这一点。此外，在不同亚组中可观察到发病率和生存模式的差异。
随着时间推移观察到头颈癌发病率呈波动模式，生存率不断提高。
