含乙酸的生物相容壳聚糖薄膜对有包膜和无包膜病毒表现出强效抗病毒活性。

Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain.

Int J Mol Sci. 2023 Jul 27;24(15):12028. doi: 10.3390/ijms241512028.

Chitosan films were prepared by solvent casting using an acetic acid-based solution. The films that were developed contained 15.49% of acetic acid solution (10% /) and showed biocompatibility in vitro in human keratinocyte HaCaT cells and potent antiviral activity against both enveloped and non-enveloped viruses. The results showed up to 99.98% and 99.92% viral inactivation against the phi 6 enveloped bacteriophage and MS2 non-enveloped bacteriophage, respectively, suggesting that this chitosan/acetic acid film is a promising material for biomedical applications that require biodegradable broad-spectrum antiviral materials.

壳聚糖薄膜采用基于醋酸的溶液通过溶剂浇铸法制备。所开发的薄膜含有 15.49%的醋酸溶液（10%/），在体外对人角质形成细胞 HaCaT 细胞具有生物相容性，并且对包膜和非包膜病毒均具有强大的抗病毒活性。结果表明，该壳聚糖/醋酸薄膜对包膜的 phi 6 噬菌体和非包膜的 MS2 噬菌体的病毒灭活率分别高达 99.98%和 99.92%，表明该壳聚糖/醋酸薄膜是一种很有前途的生物医学应用材料，可用于需要可生物降解的广谱抗病毒材料的领域。