Satou Ryouichi, Ueno Susumu, Kamijo Hideyuki, Sugihara Naoki
Department of Epidemiology and Public Health, Tokyo Dental College, Tokyo 101-0061, Japan.
Department of Occupational Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Fukuoka 807-8555, Japan.
Materials (Basel). 2023 Jul 25;16(15):5230. doi: 10.3390/ma16155230.
Sodium monofluorophosphate (NaFPO, MFP) is mainly used as an ingredient in fluoride-based dentifrices as it has a high safety profile, with one-third of the toxicity of sodium fluoride (NaF), as well as the ability to reach deep into the dentin. The purpose of this study was to assess the prevention of dentin erosion by MFP upon exposure to citric acid, which has a chelating effect, and to compare the effects to those of the conventional acidulated phosphate fluoride (APF) application method. Bovine dentin was used, and four groups were created: (i) APF (9000 ppmF, pH 3.6) 4 min group; (ii) acidulated phosphate MFP (AP-MFP, 9000 ppmF, pH 3.6) 4 min group; (iii) AP-MFP 2 min + APF 2 min (dual) group; and (iv) no fluoride application (control) group. Compared with the conventional APF application method, the application of AP-MFP was shown to significantly reduce substantial defects, mineral loss, and lesion depth; better maintain Vickers hardness; and promote the homogenous aggregation of fine CaF particles to seal the dentin tubules, enhancing acid resistance in their vicinity. The ΔZ value of the AP-MFP group was 2679 ± 290.2 vol% μm, significantly smaller than the APF group's 3806 ± 257.5 vol% μm ( < 0.01). Thus, AP-MFP-based fluoride application could effectively suppress citric acid-induced demineralization and could become a new, more powerful, and biologically safer professional-care method for preventing acid-induced dentin erosion than the conventional method.
单氟磷酸钠（NaFPO₃，MFP）主要用作含氟牙膏的成分，因为它具有较高的安全性，其毒性仅为氟化钠（NaF）的三分之一，并且能够深入牙本质。本研究的目的是评估MFP在接触具有螯合作用的柠檬酸时对牙本质侵蚀的预防作用，并将其效果与传统的酸化磷酸氟（APF）应用方法进行比较。使用牛牙本质，并分为四组：（i）APF（9000 ppmF，pH 3.6）4分钟组；（ii）酸化磷酸MFP（AP-MFP，9000 ppmF，pH 3.6）4分钟组；（iii）AP-MFP 2分钟+APF 2分钟（双重）组；以及（iv）不应用氟化物（对照）组。与传统的APF应用方法相比，AP-MFP的应用显示出能显著减少实质性缺损、矿物质损失和病变深度；更好地保持维氏硬度；并促进细小CaF颗粒的均匀聚集以封闭牙本质小管，增强其附近的耐酸性。AP-MFP组的ΔZ值为2679±290.2 vol%μm，显著小于APF组的3806±257.5 vol%μm（P<0.01）。因此，基于AP-MFP的氟化物应用可以有效抑制柠檬酸诱导的脱矿作用，并且可能成为一种比传统方法更强大、生物安全性更高的预防酸诱导牙本质侵蚀的专业护理新方法。
