叶精油和 - 石竹烯对 2-羟丙基--环糊精的包合物的除草剂和细胞遗传毒性活性。
Herbicide and Cytogenotoxic Activity of Inclusion Complexes of Leaf Essential Oil and -Caryophyllene on 2-Hydroxypropyl--cyclodextrin.
机构信息
Departament of Chemistry, Federal University of Viçosa (UFV), Av. Peter Henry Rolfs, s/n, Campus Universitário, Viçosa 36570-000, MG, Brazil.
Department of Biology, Federal University of Espírito Santo (UFES), Alto Universitário, s/n, Guararema, Alegre 29500-000, ES, Brazil.
出版信息
Molecules. 2023 Aug 6;28(15):5909. doi: 10.3390/molecules28155909.
The present investigation aimed to develop inclusion complexes (ICs) from (GAU) essential oil (EO) and its major compound -caryophyllene (-CAR), and to evaluate their herbicidal (against and ) and cytogenotoxic (on ) activities. The ICs were obtained using 2-hydroxypropyl--cyclodextrin (HPCD) and they were prepared to avoid or reduce the volatility and degradation of GAU EO and -CAR. The ICs obtained showed a complexation efficiency of 91.5 and 83.9% for GAU EO and -CAR, respectively. The IC of GAU EO at a concentration of 3000 µg mL displayed a significant effect against weed species and . However, the -CAR IC at a concentration of 3000 µg mL was effective only on . In addition, the cytogenotoxic activity evaluation revealed that there was a reduction in the mitotic index and an increase in chromosomal abnormalities. The produced ICs were able to protect the EO and -CAR from volatility and degradation, with a high thermal stability, and they also enabled the solubilization of the EO and -CAR in water without the addition of an organic solvent. Therefore, it is possible to indicate the obtained products as potential candidates for commercial exploration since the ICs allow the complexed EO to exhibit a more stable chemical constitution than pure EO under storage conditions.
本研究旨在制备 （GAU）精油（EO）及其主要化合物 - 石竹烯（-CAR）的包合物（ICs），并评价其除草（对 和 ）和细胞遗传毒性（对 ）活性。使用 2-羟丙基--环糊精（HPCD）获得 ICs，以避免或减少 GAU EO 和 -CAR 的挥发性和降解。获得的 ICs 对浓度为 3000 µg mL 的 GAU EO 和 -CAR 的包合效率分别为 91.5%和 83.9%。浓度为 3000 µg mL 的 GAU EO 的 IC 对杂草物种 和 表现出显著的除草效果。然而，浓度为 3000 µg mL 的 -CAR IC 仅对 有效。此外，细胞遗传毒性活性评估显示，有丝分裂指数降低，染色体异常增加。所制备的 ICs 能够保护 EO 和 -CAR 免受挥发性和降解的影响，具有高热稳定性，并且还能够使 EO 和 -CAR 在水中溶解，而无需添加有机溶剂。因此，可以指出所获得的产品是商业探索的潜在候选物，因为 ICs 允许复合 EO 在储存条件下表现出比纯 EO 更稳定的化学组成。
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