Taiwo Olayombo M, Olaoluwa Olaoluwa O, Aiyelaagbe Olapeju O, Schmidt Thomas J
Department of Chemistry, University of Ibadan, Ibadan 200284, Nigeria.
University of Münster, Institute of Pharmaceutical Biology and Phytochemistry (IPBP), PharmaCampus, Corrensstrasse 48, D-48149 Münster, Germany.
Plants (Basel). 2023 Jul 28;12(15):2801. doi: 10.3390/plants12152801.
The phytochemical investigation of the ethylacetate fraction of an ethanolic extract obtained from the stem bark of (Moraceae) led to the isolation of four flavonoids: (2)-eriodictyol (), 2'- hydroxygenistein (), erycibenin A (), and genistein (); a dihydrobenzofuran: moracin P (); a coumarin: peucedanol (); and an apocarotenoid terpenoid: dihydrophaseic acid (). These were identified via 1D and 2D nuclear magnetic resonance spectroscopy (NMR) and ultra-high-resolution liquid chromatography-quadrupole time-of-flight mass spectroscopy (UHPLC-QTOF MS). Moracin P () is being reported for the first time in the genus while the others are known compounds ( and ) isolated previously from the genus but being reported for the first time from the species . Their antimicrobial activity against various pathogens (five bacteria: , , , , and ; two fungi: and ) was tested. The mixture of genistein and moracin P (+) exhibited strong activity against (MIC < 0.0039 mg/mL), whereas dihydrophaseic acid () was the most active against and (MIC = 0.0078 and <0.0039 mg/mL, respectively). These compounds might be considered potential antimicrobial agents with the potential to be starting points for the development of antimicrobial drugs.
对桑科植物[具体植物名称未给出]茎皮乙醇提取物的乙酸乙酯馏分进行植物化学研究，从中分离出四种黄酮类化合物：（2）-圣草酚（）、2'-羟基染料木素（）、刺桐贝宁A（）和染料木素（）；一种二氢苯并呋喃：桑色素P（）；一种香豆素：前胡醇（）；以及一种类胡萝卜素萜类化合物：二氢阿魏酸（）。这些化合物通过一维和二维核磁共振光谱（NMR）以及超高效液相色谱-四极杆飞行时间质谱（UHPLC-QTOF MS）进行鉴定。桑色素P（）在该属植物中首次被报道，而其他化合物是先前从该属植物中分离出的已知化合物（和），但在该物种中首次被报道。测试了它们对多种病原体（五种细菌：[具体细菌名称未给出]、[具体细菌名称未给出]、[具体细菌名称未给出]、[具体细菌名称未给出]和[具体细菌名称未给出]；两种真菌：[具体真菌名称未给出]和[具体真菌名称未给出]）的抗菌活性。染料木素和桑色素P的混合物（+）对[具体细菌名称未给出]表现出强活性（MIC < 0.0039 mg/mL），而二氢阿魏酸（）对[具体细菌名称未给出]和[具体细菌名称未给出]活性最强（MIC分别为0.0078和<0.0039 mg/mL）。这些化合物可能被视为潜在的抗菌剂，有潜力成为抗菌药物开发的起点。
