Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Nutrients. 2023 Jul 25;15(15):3298. doi: 10.3390/nu15153298.
High prostate-specific antigen (PSA) levels can indicate potential prostate problems and are a warning sign of prostate cancer. The impact of antioxidants on the PSA of generally healthy men is understudied. This study aims to evaluate 14 dietary and endogenous antioxidants associated with PSA levels for United States (US) men. We assessed 7398 men using the 2003-2010 US population-based National Health and Nutrition Examination Survey (NHANES). The PSA levels were categorized into three groups: Normal, borderline, and elevated levels. We performed analyses for middle-aged and older groups aged 40-64.9 and ≥65, respectively. The weighted multinomial regressions were performed to evaluate antioxidants associated with the PSA status. For results, 0.3% and 3.4% of middle-aged and older men, respectively, had elevated PSA (>10 ng/mL). Men with a higher serum albumin level had a lower risk of an elevated PSA, adjusting for age. The magnitude of albumin's impact on PSA is larger in middle-aged men than in older men (OR of elevated PSA = 0.82 and 0.90, respectively, interaction = 0.002). Other antioxidants are not associated with PSA. Our findings support men with low serum albumin tend to have an elevated PSA level, so related interventions can be considered to decrease PSA for maintaining prostate health.
高前列腺特异性抗原（PSA）水平可能表明存在前列腺问题，并是前列腺癌的警告信号。抗氧化剂对一般健康男性 PSA 的影响研究较少。本研究旨在评估与美国男性 PSA 水平相关的 14 种饮食和内源性抗氧化剂。我们使用 2003-2010 年基于人群的美国国家健康和营养检查调查（NHANES）评估了 7398 名男性。PSA 水平分为三组：正常、临界值和升高。我们对 40-64.9 岁和≥65 岁的中年和老年组分别进行了分析。我们进行了加权多项回归分析，以评估与 PSA 状态相关的抗氧化剂。结果显示，分别有 0.3%和 3.4%的中年和老年男性 PSA 升高（>10ng/ml）。血清白蛋白水平较高的男性，调整年龄后，PSA 升高的风险较低。白蛋白对 PSA 的影响在中年男性中大于老年男性（PSA 升高的 OR 分别为 0.82 和 0.90，交互作用=0.002）。其他抗氧化剂与 PSA 无关。我们的研究结果支持血清白蛋白水平低的男性往往 PSA 水平升高，因此可以考虑相关干预措施来降低 PSA，以维持前列腺健康。
