Gao Simeng, Li Shaojie, Wu Baofang, Wang Jiayin, Ding Sijuan, Tang Zhaohui
The Central Hospital of Yongzhou, Yongzhou, Hu Nan, 425000, China.
The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, 362000, China.
BMC Urol. 2025 Jan 7;25(1):3. doi: 10.1186/s12894-024-01687-2.
The albumin-globulin ratio (AGR) influences the development of prostate cancer; however, the relationship between AGR and prostate-specific antigen (PSA) has not been reported.
This cross-sectional investigation used comprehensive AGR versus PSA data from men with 40 years of age and older, who participated in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2010, spanning 4 investigation cycles, as only these cycles contained complete PSA data. To evaluate the nonlinear relationship between the ARG and PSA level, a regression utilizing smoothed curve fitting (penalized spline approach) and a generalized additive model (GAM) were employed. A two-segment linear regression model was used to conduct threshold effect evaluations. Lastly, subgroup analyses were carried out along with interaction tests.
This study included 5,376 subjects, whose total serum PSA (mean ± standard deviation) was 1.83 ± 3.34, and its level decreased roughly with increasing quartiles of AGR. In the fully-adjusted model, AGR was negatively correlated with the likelihood of PSA, and this relationship persisted across subgroups (trend > 0.05). The PSA was characterized by an "L"-shaped curve with an inflection point. On the left side of the inflection point (K = 1.32), there was a negative relationship between AGR and PSA.
In the United States, among men over 40 years of age without prostate diseases, AGR demonstrated a nonlinear relationship with PSA, negatively correlating when AGR was below 1.32.
Not applicable.
白蛋白与球蛋白比值（AGR）会影响前列腺癌的发展；然而，AGR与前列腺特异性抗原（PSA）之间的关系尚未见报道。
本横断面研究使用了2003年至2010年参加美国国家健康与营养检查调查（NHANES）的40岁及以上男性的AGR与PSA综合数据，涵盖4个调查周期，因为只有这些周期包含完整的PSA数据。为评估AGR与PSA水平之间的非线性关系，采用了利用平滑曲线拟合（惩罚样条法）的回归分析和广义相加模型（GAM）。使用两段线性回归模型进行阈值效应评估。最后，进行了亚组分析和交互作用检验。
本研究纳入5376名受试者，其血清总PSA（均值±标准差）为1.83±3.34，且其水平大致随AGR四分位数的增加而降低。在完全调整模型中，AGR与PSA的可能性呈负相关，且这种关系在各亚组中均持续存在（趋势>0.05）。PSA呈现出一条有拐点的“L”形曲线。在拐点左侧（K = 1.32），AGR与PSA呈负相关。
在美国，40岁以上无前列腺疾病的男性中，AGR与PSA呈非线性关系，当AGR低于1.32时呈负相关。
不适用。
