Hannover Medical School, Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Institute of Food Science and Human Nutrition, Am Kleinen Felde 30, 30167 Hannover, Germany.
Nutrients. 2023 Jul 27;15(15):3344. doi: 10.3390/nu15153344.
Although numerous studies have been published investigating the relationship between various dietary components and inflammatory periodontal disease, it has not yet been possible to clearly distinguish between periodontally healthy and unhealthy diets. This clinical study aimed to assess the association of specific food ingredients and physical activity on local and systemic inflammatory signs in experimentally induced gingivitis. Thirty-nine non-smoking periodontally healthy volunteers (mean age 23.2 ± 3.8 years) refrained from oral hygiene in the right maxilla for 21 days to induce an experimental gingivitis. Clinical examination (baseline and day 21) included plaque index, bleeding on probing (BOP), gingival crevicular fluid volume and high sensitive C-reactive protein levels (blood sample). Accompanying the intervention, volunteers documented with validated questionnaires their physical activity converted into metabolic equivalent (MET) and their nutrition converted into the dietary inflammatory index (DII). Significantly lower BOP ( = 0.039) was found for subjects with a more anti-inflammatory DII than for those with a more pro-inflammatory DII; higher MET values were correlated with lower BOP at day 21 (correlation coefficient -0.36). The results show an influence of nutrition and physical activity on periodontal inflammation signs. The DII may be a suitable parameter to verify the relationship between nutrition and inflammatory periodontal diseases.
尽管已经有许多研究探讨了各种饮食成分与炎症性牙周病之间的关系，但仍然无法明确区分牙周健康和不健康的饮食。本临床研究旨在评估特定食物成分和身体活动与实验性龈炎局部和全身炎症标志物之间的关联。39 名非吸烟牙周健康志愿者（平均年龄 23.2 ± 3.8 岁）在右侧上颌牙列中 21 天不进行口腔卫生，以诱导实验性龈炎。临床检查（基线和第 21 天）包括菌斑指数、探诊出血（BOP）、龈沟液量和高敏 C 反应蛋白水平（血样）。在干预过程中，志愿者使用经过验证的问卷记录他们的身体活动转换为代谢当量（MET）和他们的营养转换为饮食炎症指数（DII）。具有更抗炎性 DII 的受试者的 BOP 明显较低（= 0.039），而具有更促炎性 DII 的受试者的 BOP 较高；较高的 MET 值与第 21 天的 BOP 降低相关（相关系数 -0.36）。结果表明营养和身体活动对牙周炎症标志物有影响。DII 可能是验证营养与炎症性牙周病之间关系的合适参数。
