Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
NeckShoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China.
J Affect Disord. 2023 Nov 1;340:347-354. doi: 10.1016/j.jad.2023.08.053. Epub 2023 Aug 10.
The association between dietary intake and depression is receiving increasing attention. However, the relationship between depressive symptoms and niacin intake is still unclear. The purpose of this study was to explore the association between niacin intake and depressive symptoms.
We used univariate analysis and multivariate logistic regression equations to explore the association between covariates or niacin intake and depression. Generalized additive models and smoothing fitted curves were used to examine the presence of nonlinear relationships. Upon finding a nonlinear relationship, a recursive algorithm was used to calculate the inflection point . Population differences were also explored through stratified analysis.
In the model adjusted for all covariates，the ORs (95 % CI) for the association between niacin intake and depression were 0.94 (0.87, 1.01), which was no statistical significance. However, the result of the linear trend test with quartiles of niacin intake indicated the association between niacin intake and depression may be U-shaped. The generalized additive model confirmed this U-shaped relationship, finding an inflection point (26.6 mg/d). An opposite relationship was observed before and after the inflection point, with ORs (95 % CI) of 0.77 (0.68, 0.87) before the inflection point and 1.13 (1.01, 1.28) after the inflection point. The association in men, Mexican American, White, adults aged<40, and BMI <30 was consistent with the overall tendency.
We found a U-shaped association between niacin intake and depression in the general American population, and the same association was observed in men, Mexican American, White, adults aged < 40, and BMI < 30.
饮食摄入与抑郁之间的关系越来越受到关注。然而，抑郁症状与烟酸摄入之间的关系尚不清楚。本研究旨在探讨烟酸摄入与抑郁症状之间的关系。
我们使用单变量分析和多变量逻辑回归方程来探讨协变量或烟酸摄入与抑郁之间的关系。使用广义加性模型和平滑拟合曲线来检查是否存在非线性关系。在发现非线性关系时，使用递归算法计算拐点。还通过分层分析探讨了人群差异。
在调整所有协变量的模型中，烟酸摄入与抑郁之间的关联的 OR（95%CI）为 0.94（0.87，1.01），无统计学意义。然而，线性趋势检验的结果表明，烟酸摄入与抑郁之间的关系可能呈 U 形。广义加性模型证实了这种 U 形关系，发现拐点（26.6mg/d）。烟酸摄入与抑郁之间的关系呈 U 形，拐点前和拐点后的 OR（95%CI）分别为 0.77（0.68，0.87）和 1.13（1.01，1.28）。在拐点前和拐点后，男性、墨西哥裔美国人、白人、年龄<40 岁和 BMI<30 的人群中观察到相反的关系。
我们发现，在美国一般人群中，烟酸摄入与抑郁之间存在 U 形关联，这种关联在男性、墨西哥裔美国人、白人和年龄<40 岁和 BMI<30 的人群中也存在。
