Qiu Jie-Yu, Zhang Wen-Hui, Zhu Xiao-Ming, Wu Li-Da, Huang Ji-Hua, Zhang Jie
Department of Cardiology, XiShan People's Hospital of Wuxi City, Wuxi, China.
Department of Hepatobiliary Surgery, Beijing Chao-Yang Hospital Affiliated to Capital Medical University, Beijing, China.
Front Nutr. 2024 Jul 19;11:1391023. doi: 10.3389/fnut.2024.1391023. eCollection 2024.
This study aims to explore the association between niacin intake and stroke within a diverse, multi-ethnic population.
A stringent set of inclusion and exclusion criteria led to the enrollment of 39,721 participants from the National Health and Nutrition Examination Survey (NHANES). Two interviews were conducted to recall dietary intake, and the USDA's Food and Nutrient Database for Dietary Studies (FNDDS) was utilized to calculate niacin intake based on dietary recall results. Weighted multivariate logistic regression was employed to examine the correlation between niacin and stroke, with a simultaneous exploration of potential nonlinear relationships using restricted cubic spline (RCS) regression.
A comprehensive analysis of baseline data revealed that patients with stroke history had lower niacin intake levels. Both RCS analysis and multivariate logistic regression indicated a negative nonlinear association between niacin intake and stroke. The dose-response relationship exhibited a non-linear pattern within the range of dietary niacin intake. Prior to the inflection point (21.8 mg) in the non-linear correlation between niacin intake and stroke risk, there exists a marked decline in the risk of stroke as niacin intake increases. Following the inflection point, the deceleration in the decreasing trend of stroke risk with increasing niacin intake becomes evident. The inflection points exhibit variations across diverse populations.
This investigation establishes a negative nonlinear association between niacin intake and stroke in the broader American population.
本研究旨在探讨在一个多样化的多民族人群中烟酸摄入量与中风之间的关联。
一套严格的纳入和排除标准使得来自国家健康与营养检查调查（NHANES）的39721名参与者得以入选。进行了两次访谈以回忆饮食摄入量，并利用美国农业部饮食研究的食品和营养数据库（FNDDS）根据饮食回忆结果计算烟酸摄入量。采用加权多因素逻辑回归来检验烟酸与中风之间的相关性，同时使用限制立方样条（RCS）回归探索潜在的非线性关系。
对基线数据的全面分析显示，有中风病史的患者烟酸摄入量较低。RCS分析和多因素逻辑回归均表明烟酸摄入量与中风之间存在负向非线性关联。在饮食烟酸摄入量范围内，剂量反应关系呈现出非线性模式。在烟酸摄入量与中风风险的非线性相关性的拐点（21.8毫克）之前，随着烟酸摄入量的增加，中风风险显著下降。在拐点之后，随着烟酸摄入量增加，中风风险下降趋势的减缓变得明显。不同人群的拐点存在差异。
本调查在更广泛的美国人群中确立了烟酸摄入量与中风之间的负向非线性关联。
