Sesso R C, Ramos O L, Pereira A B
Clin Nephrol. 1986 Aug;26(2):55-60.
Rheumatoid factors (RF) were measured in sera from 75 patients with acute poststreptococcal glomerulonephritis (APSGN) and compared with normal controls, patients with rheumatoid arthritis in activity and acute rheumatic fever. Using two sensitive and specific solid phase radioimmunoassays, IgM-RF and IgG-RF were detected, respectively, in 15% and 32% of the patients with APSGN. A positive correlation (r = 0.37, n = 75, p less than 0.05) was obtained between serum levels of IgG-RF and circulating immune complexes determined by conglutinin assay. Chromatographic studies in serum from two patients with APSGN demonstrated that the circulating IgG-RFs were mainly free, not complexed. It is suggested that RFs, particularly of the IgG class, may participate in the pathogenesis of the renal injury in some patients with APSGN.
对75例急性链球菌感染后肾小球肾炎（APSGN）患者的血清进行类风湿因子（RF）检测，并与正常对照组、活动期类风湿关节炎患者及急性风湿热患者进行比较。采用两种灵敏且特异的固相放射免疫测定法，分别在15%的APSGN患者中检测到IgM-RF，在32%的患者中检测到IgG-RF。通过胶固素测定法测定的血清IgG-RF水平与循环免疫复合物之间呈正相关（r = 0.37，n = 75，p < 0.05）。对两名APSGN患者血清的色谱研究表明，循环中的IgG-RF主要是游离的，而非复合形式。提示RF，尤其是IgG类RF，可能参与了部分APSGN患者肾损伤的发病机制。
