Altern Ther Health Med. 2023 Nov;29(8):214-220.
To investigate the correlation between the serum hypoxia-inducible factor-1α, uric acid, inflammatory factor levels, and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
The clinical data of patients with chronic obstructive pulmonary disease (40 cases) from March 2020 to March 2021 were retrospectively analyzed. According to the disease condition in patients with chronic obstructive pulmonary disease, they were divided into acute exacerbation stage (observation group, 20 cases) and stable stage (control group, 20 cases). All patients' basic data such as age, sex, and course of disease were collected and sorted out, and the serum hypoxia-inducible factor-1α, uric acid, inflammatory factor levels (procalcitonin, interleukin-6, and high-sensitivity C-reactive protein), and the index of their pulmonary function were measured. The profiles of serum hypoxia-inducible factor-1 alpha and uric acid, levels of inflammatory factors, and pulmonary function indices were measured and compared between the observation and control groups. The correlation between patients' serum hypoxia-inducible factor-1α, uric acid, and inflammatory factors and lung function was analyzed.
There was no difference in basic data between the observation group and the control group, P > .05. Serum hypoxia-inducible factor-1α, uric acid, and levels of inflammatory factors were all higher in the observation group than the control group, and the differences are significant (P < .05). There was significant difference in lung function indexes between the observation group and the control group (P < .05). Serum hypoxia-inducible factor-1α, uric acid, and inflammatory factor levels were negatively associated with pulmonary function indices.
The more serious the condition of AECOPD patients is, the levels of serum hypoxia inducible factor -1α, uric acid and inflammatory factors gradually increase, and the lung function tends to decline.
探讨慢性阻塞性肺疾病急性加重期（AECOPD）患者血清低氧诱导因子-1α、尿酸、炎性因子水平与肺功能的相关性。
回顾性分析 2020 年 3 月至 2021 年 3 月间收治的慢性阻塞性肺疾病患者 40 例的临床资料。根据慢性阻塞性肺疾病患者病情，将其分为急性加重期（观察组，20 例）和稳定期（对照组，20 例）。收集并整理所有患者的年龄、性别、病程等基本资料，并检测血清低氧诱导因子-1α、尿酸、炎性因子水平（降钙素原、白细胞介素-6、高敏 C 反应蛋白）和肺功能指标，比较观察组与对照组的血清低氧诱导因子-1α、尿酸、炎性因子水平和肺功能指标变化情况。分析患者血清低氧诱导因子-1α、尿酸和炎性因子与肺功能的相关性。
观察组与对照组基本资料比较，差异无统计学意义（P＞0.05）。观察组血清低氧诱导因子-1α、尿酸、炎性因子水平均高于对照组，差异有统计学意义（P＜0.05）。观察组与对照组肺功能指标比较，差异有统计学意义（P＜0.05）。血清低氧诱导因子-1α、尿酸、炎性因子水平与肺功能指标呈负相关。
AECOPD 患者病情越严重，其血清低氧诱导因子-1α、尿酸和炎性因子水平逐渐升高，肺功能呈下降趋势。
