Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Trends Genet. 2023 Dec;39(12):889-891. doi: 10.1016/j.tig.2023.07.007. Epub 2023 Aug 12.
In aged animals from worms to humans, transcriptional elongation rates are faster, leading to changes in transcript quality and alternative splicing. Recent work by Debès et al. shows how interventions that slow elongation rates, such as mutating RNA polymerase II (Pol II) or increasing nucleosome density to impose transcriptional 'traffic', delay senescence and promote longevity.
在从蠕虫到人类的老年动物中，转录延伸率更快，导致转录本质量和可变剪接发生变化。Debès 等人的最新研究表明，通过改变 RNA 聚合酶 II（Pol II）或增加核小体密度来施加转录“流量”等减缓延伸率的干预措施如何延缓衰老并延长寿命。
