Gholamalizadeh Maryam, Ardekanizadeh Naeemeh Hassanpour, Aghakhaninejad Zohreh, Mohammadi Saeideh, Majidi Nazanin, Masoumvand Mohammad, Bakhshimoghaddam Farnush, Ahmadzadeh Mina, Tajadod Shirin, Askarpour Seyed Ali, Khoshdooz Sara, Kalantari Naser, Doaei Saeid
Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran.
Eur J Obstet Gynecol Reprod Biol X. 2023 Jul 19;19:100217. doi: 10.1016/j.eurox.2023.100217. eCollection 2023 Sep.
Recent studies reported that complementary therapy including dietary supplements may has a beneficial role in cervical cancer. However, the results are inconsistent. This study aimed to investigate the association between cervical cancer and dietary supplements.
A systematic literature review was conducted to summarize and quantify the most recent findings on dietary supplement and cervical cancer. Several databases were checked for relevant publications published in English up to March 2023. Of the 32 articles identified, only 20 met the inclusion criteria and were included.
Women with cervical intraepithelial neoplasia may benefit from folate supplementation against oxidative stress and inflammation. Vitamin D may reduce oxidative stress and may have a therapeutic effect. Zinc promotes the clearance of the human papilloma virus and reduces the chance of viral infection. The use of probiotic supplements may improve the complications associated with chemotherapy in patients with cervical cancer, such as diarrhea and abdominal pain. Radiotherapy and chemotherapy complications may also be reduced by omega-3 fatty acids.
Some dietary supplements including folate, vitamin D, zinc, probiotics, and omega-3 fatty acids may have beneficial effects in patients with cervical cancer. Further studies are warranted to confirm these results.
近期研究报告称，包括膳食补充剂在内的补充疗法可能对宫颈癌具有有益作用。然而，结果并不一致。本研究旨在调查宫颈癌与膳食补充剂之间的关联。
进行了一项系统的文献综述，以总结和量化关于膳食补充剂与宫颈癌的最新研究结果。检索了多个数据库，查找截至2023年3月发表的英文相关出版物。在识别出的32篇文章中，只有20篇符合纳入标准并被纳入。
宫颈上皮内瘤变女性可能从补充叶酸中受益，以对抗氧化应激和炎症。维生素D可能减轻氧化应激并可能具有治疗作用。锌可促进人乳头瘤病毒的清除并降低病毒感染几率。使用益生菌补充剂可能改善宫颈癌患者化疗相关的并发症，如腹泻和腹痛。ω-3脂肪酸也可能减少放疗和化疗并发症。
包括叶酸、维生素D、锌、益生菌和ω-3脂肪酸在内的一些膳食补充剂可能对宫颈癌患者具有有益作用。有必要进行进一步研究以证实这些结果。
