Department of Ophthalmology, NMC Specialty Hospital, Al Ain, Abu Dhabi, UAE.
Indian J Ophthalmol. 2019 Feb;67(2):292-294. doi: 10.4103/ijo.IJO_929_18.
A 30-year-old insomniac, an off-label user of quetiapine, presented with blurring of central vision, eventually diagnosed as central serous chorioretinopathy. A potential association was suspected based on the drug's actions on the autonomic nervous system. He showed improvement on drug withdrawal; then he unwittingly resumed quetiapine and had a recurrence. Possible underlying mechanisms that include alteration in choroidal perfusion through serotonin and dopamine receptors are discussed. Although retinal vein occlusions and pigment epithelial detachment have been described with quetiapine, to the author's knowledge, this is the first case report of quetiapine-associated central serous chorioretinopathy.
一位 30 岁的失眠症患者，非适应证使用喹硫平，出现中央视力模糊，最终被诊断为中心性浆液性脉络膜视网膜病变。根据药物对自主神经系统的作用，怀疑存在潜在关联。停药后他的病情有所改善；然后他无意中又重新开始使用喹硫平，病情复发。通过 5-羟色胺和多巴胺受体改变脉络膜灌注等可能的潜在机制进行了讨论。虽然已有报道称喹硫平与视网膜静脉阻塞和色素上皮脱离有关，但据作者所知，这是首例喹硫平相关性中心性浆液性脉络膜视网膜病变的病例报告。
