Karmilkar Kunal, Patel Aditi, Patel Nehal
Neurology, Edward Via College of Osteopathic Medicine, Monroe, USA.
Internal Medicine, Rapides Regional Medical Center, Alexandria, USA.
Cureus. 2023 Jul 12;15(7):e41788. doi: 10.7759/cureus.41788. eCollection 2023 Jul.
While COVID-19 is known to cause common neurological manifestations such as loss of taste and smell, headaches, and myalgias, rare and severe neurological complications can also occur. We describe the hospitalization of a middle-aged Caucasian woman who presented with altered mental status and an absence of moderate-severe pulmonary symptoms. The patient tested positive for COVID-19 and experienced a tonic-clonic seizure six days after admission. Diagnostic testing, including cerebrospinal fluid analysis, blood cultures, urine cultures, brain imaging, and electroencephalograms were unremarkable, indicating a global encephalopathic state. This case highlights the need for clinicians to anticipate neurological complications when managing patients with COVID-19, especially when respiratory symptoms are minimal or absent. Moreover, further research on COVID-19-induced encephalopathy is crucial to improve patient outcomes and inform clinical practice.
虽然已知新冠病毒会引发常见的神经症状，如味觉和嗅觉丧失、头痛和肌痛，但也可能出现罕见且严重的神经并发症。我们描述了一名中年白人女性的住院情况，她出现了精神状态改变，且没有中度至重度肺部症状。该患者新冠病毒检测呈阳性，入院六天后发生了强直阵挛性癫痫发作。包括脑脊液分析、血培养、尿培养、脑部成像和脑电图在内的诊断测试均无异常，表明处于全面性脑病状态。该病例凸显了临床医生在管理新冠患者时，尤其是当呼吸道症状轻微或不存在时，需要预见到神经并发症。此外，对新冠病毒诱发的脑病进行进一步研究对于改善患者预后和指导临床实践至关重要。
