Comparative in vitro activity of ciprofloxacin and other antimicrobial agents against aminoglycoside-resistant gram-negative rods and microorganisms isolated from patients with bacteremia.

The comparative in vitro activity of ciprofloxacin, norfloxacin, aztreonam, cefotaxime, ceftazidime, mezlocillin, azlocillin, and tobramycin was evaluated against 188 isolates from bacteremic patients and 161 aminoglycoside-resistant gram-negative rods. Although some streptococcal (particularly enterococcal) blood isolates, Pseudomonas spp., and nonfermentative gram-negative rods were not inhibited by ciprofloxacin, it was nevertheless the most active compound tested against both microorganism groups.