Marampon Francesco, Parisi Martina, Cicco Piero Rodolfo, Serpone Maria, Tomaciello Miriam, Musio Daniela, De Felice Francesca, Tombolini Vincenzo
Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, Rome, Italy.
BJR Case Rep. 2023 Jun 13;9(4):20200142. doi: 10.1259/bjrcr.20200142. eCollection 2023 Aug.
Skin metastases from prostate cancer (PCa) are rare, cause considerable discomfort, and usually indicate advanced disease and a poor prognosis. To date, literature accounts for no more than 88 cases of skin metastasis from PCa, and radiation therapy (RT) is not considered a standard treatment option. Here, we have described a rare case of skin localization of castration-resistant metastatic PCa, which occurred in a 75-year-old male previously treated with RT for PCa, 11 years earlier. The skin lesions, which progressively appeared in different areas of the chest wall, were successfully treated with electron beam RT (900 cGy, for 3 consecutive days). Five months after irradiating skin metastases, the patient showed general fair conditions and no longer developed other skin lesions in the areas already treated or elsewhere. This report describes a scarce case of cutaneous metastases from PCa, underlying the crucial role of RT as a definitive palliative treatment that should be used to limit systemic chemotherapy-related toxicity.
前列腺癌（PCa）的皮肤转移罕见，会引起相当大的不适，通常提示疾病进展及预后不良。迄今为止，文献报道的PCa皮肤转移病例不超过88例，放射治疗（RT）不被视为标准治疗选择。在此，我们描述了一例去势抵抗性转移性PCa皮肤定位的罕见病例，该病例发生在一名75岁男性身上，他11年前曾因PCa接受过RT治疗。胸壁不同部位逐渐出现的皮肤病变通过电子束RT（900 cGy，连续3天）成功治疗。皮肤转移灶放疗5个月后，患者总体状况良好，已治疗部位及其他部位未再出现其他皮肤病变。本报告描述了一例罕见的PCa皮肤转移病例，强调了RT作为确定性姑息治疗的关键作用，应用RT可限制全身化疗相关毒性。
