Assiry Ali A, Ahmed Naveed, Almuaddi Abdulmajeed, Saif Ahmed, Alshahrani Mohammed Abdulrahman, Mohamed Roshan Noor, Karobari Mohmed Isaqali
Preventive Dental Science Department, Faculty of Dentistry Najran University Najran Saudi Arabia.
Department of Medical Microbiology and Parasitology, School of Medical Sciences University Sains Malaysia Kota Bharu Malaysia.
Food Sci Nutr. 2023 Jun 1;11(8):4853-4860. doi: 10.1002/fsn3.3462. eCollection 2023 Aug.
Antibiotic resistance is rising across the world. For a very long time, bitter ginger () has been used as one of the most popular herbal remedies to treat a wide range of common diseases. Ginger has been shown to have antioxidant and antibacterial activity. It has various bioactive chemicals that might be utilized as an alternative treatment option for many infectious diseases. The present study aimed to examine the biochemical profile of ginger, antioxidant, and antibacterial activity against selective endodontic microbes. Antioxidant was measured using DPPH and antibacterial activity was performed using disk diffusion tests. , , spp., and spp. were tested for antibacterial activity. Before evaluating the dried extracts, all solvents were eliminated using rotary evaporation. The obtained IC50 value revealed that ethanol extract had the greatest antioxidant activity. Concerning each bacterium, the plant extracts demonstrated considerable antibacterial activity ( = .001). Ethanol extracts showed the strongest antibacterial activity against the studied microorganisms. This study highlights that the () is a strong antibacterial herb against multidrug-resistant (MDR) gram-positive bacteria. It may also be employed as a possible natural antioxidant source.
抗生素耐药性正在全球范围内上升。长期以来，干姜一直是治疗多种常见疾病最常用的草药之一。生姜已被证明具有抗氧化和抗菌活性。它含有多种生物活性化学物质，可能被用作许多传染病的替代治疗选择。本研究旨在检测生姜的生化特性、抗氧化和对选择性牙髓微生物的抗菌活性。使用DPPH法测定抗氧化活性，采用纸片扩散法进行抗菌活性检测。对粪肠球菌、金黄色葡萄球菌、变形链球菌和牙龈卟啉单胞菌进行抗菌活性测试。在评估干燥提取物之前，使用旋转蒸发法去除所有溶剂。获得的IC50值表明乙醇提取物具有最强的抗氧化活性。对于每种细菌，植物提取物均表现出显著的抗菌活性（P = 0.001）。乙醇提取物对所研究的微生物表现出最强的抗菌活性。本研究强调，干姜是一种对多重耐药（MDR）革兰氏阳性菌有强效抗菌作用的草药。它也可能被用作一种潜在的天然抗氧化剂来源。
