老年雌性大鼠的食物摄入量和体重对雌二醇的反应。

Response of food intake and body weight to estradiol in old female rats.

作者信息

Peng M T, Chiang H L, Lee L R

出版信息

Chin J Physiol. 1986;29(1):1-6.

Abstract

Changes in food intake and body weight were studied in old ovariectomized prolonged vaginal cornification female rats (27.6 +/- 3.3 (SD) months of age) implanted subcutaneously with 100%, 50% and 33% estradiol benzoate (E2)-cholestrol mixture-filled silastic capsules and were compared with similarly treated young ovariectomized female rats (4.7 +/- 0.8 months of age). Serum E2 concentration was higher in old rats than young rats in the 100% E2-filled capsule implanted group. In this group, food intake suppression by E2 was larger in old rats than in young rats. However, no age-related difference was observed, when food intake decrease was adjusted for serum E2 level by analysis of covariance. Therefore a high food intake suppression in old rats than in young rats is caused by high serum E2 concentration in old rats. Suppression of body weight increase did not show any age-related difference when adjusted for serum E2 level either.

摘要

对皮下植入填充有100%、50%和33%苯甲酸雌二醇（E2）-胆固醇混合物的硅橡胶胶囊的老龄去卵巢长期阴道角化雌性大鼠（27.6±3.3（标准差）月龄）的食物摄入量和体重变化进行了研究，并与同样处理的年轻去卵巢雌性大鼠（4.7±0.8月龄）进行了比较。在植入100% E2填充胶囊的组中，老龄大鼠的血清E2浓度高于年轻大鼠。在该组中，E2对老龄大鼠食物摄入量的抑制作用大于年轻大鼠。然而，通过协方差分析将食物摄入量的减少根据血清E2水平进行调整后，未观察到与年龄相关的差异。因此，老龄大鼠比年轻大鼠食物摄入量受到更高抑制是由老龄大鼠血清E2浓度较高所致。在根据血清E2水平进行调整后，体重增加的抑制也未显示出任何与年龄相关的差异。