Lee L R, Yu J Y, Peng M T
Neurobiol Aging. 1985 Fall;6(3):241-4. doi: 10.1016/0197-4580(85)90057-0.
Long-Evans female rats were divided into three age groups: 10 young rats (5 months of age), 7 middle-aged rats (10-13 months of age) and 6 old rats (21-27 months of age). The rats were ovariectomized and immediately implanted subcutaneously with a silastic capsule filled with estradiol benzoate (E2). Lordosis response was compared in each animal before and after the septal lesion. Serum E2 levels were 197 +/- 27 pg/ml (mean +/- SEM), 192 +/- 81 pg/ml and 405 +/- 83 pg/ml in young, middle-aged and old rats respectively. When serum E2 levels were adjusted by analysis of covariance, LQ (lordosis quotient) was 42, 36 and 61 in young, middle-aged and old rats respectively before the septal lesion and 98, 68 and 88 respectively after the septal lesion. The extent of potentiation of lordosis after the septal lesion was less in middle-aged and old rats than young rats. These results indicate that an enhanced lordosis response in aged rats is partly due to high circulating E2 levels and partly due to disinhibition of the septal region on lordosis.
将长 Evans 雌性大鼠分为三个年龄组：10 只年轻大鼠（5 月龄）、7 只中年大鼠（10 - 13 月龄）和 6 只老年大鼠（21 - 27 月龄）。对大鼠进行卵巢切除，并立即在皮下植入一个装有苯甲酸雌二醇（E2）的硅橡胶胶囊。在进行隔区损伤前后，比较每只动物的脊柱前凸反应。年轻、中年和老年大鼠的血清 E2 水平分别为 197±27 pg/ml（平均值±标准误）、192±81 pg/ml 和 405±83 pg/ml。通过协方差分析调整血清 E2 水平后，隔区损伤前年轻、中年和老年大鼠的脊柱前凸商（LQ）分别为 42、36 和 61，隔区损伤后分别为 98、68 和 88。中年和老年大鼠隔区损伤后脊柱前凸增强的程度低于年轻大鼠。这些结果表明，老年大鼠脊柱前凸反应增强部分归因于循环 E2 水平升高，部分归因于隔区对脊柱前凸的去抑制作用。
