Desai Dhruv N, Mahal Ahmed, Varshney Rajat, Obaidullah Ahmad J, Gupta Bhawna, Mohanty Pratikhya, Pattnaik Priyabrata, Mohapatra Nrusingha Charan, Mishra Snehasish, Kandi Venkataramana, Rabaan Ali A, Mohapatra Ranjan K
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Department of Medical Biochemical Analysis, College of Health Technology, Cihan University-Erbil, Erbil, Kurdistan Region, Iraq.
ACS Omega. 2023 Jul 24;8(31):27953-27968. doi: 10.1021/acsomega.3c02030. eCollection 2023 Aug 8.
Adjuvants are the important part of vaccine manufacturing as they elicit the vaccination effect and enhance the durability of the immune response through controlled release. In light of this, nanoadjuvants have shown unique broad spectrum advantages. As nanoparticles (NPs) based vaccines are fast-acting and better in terms of safety and usability parameters as compared to traditional vaccines, they have attracted the attention of researchers. A vaccine nanocarrier is another interesting and promising area for the development of next-generation vaccines for prophylaxis. This review looks at the various nanoadjuvants and their structure-function relationships. It compiles the state-of-art literature on numerous nanoadjuvants to help domain researchers orient their understanding and extend their endeavors in vaccines research and development.
佐剂是疫苗生产的重要组成部分，因为它们能引发疫苗接种效果，并通过控释增强免疫反应的持久性。鉴于此，纳米佐剂已显示出独特的广谱优势。与传统疫苗相比，基于纳米颗粒（NPs）的疫苗起效快，在安全性和可用性参数方面表现更好，因此吸引了研究人员的关注。疫苗纳米载体是开发下一代预防性疫苗的另一个有趣且有前景的领域。本综述探讨了各种纳米佐剂及其结构-功能关系。它汇编了众多纳米佐剂的最新文献，以帮助该领域的研究人员明确他们的理解，并在疫苗研发中拓展他们的努力方向。
