Lingas Elvina C
Hospital Medicine, Presbyterian Hospital, Albuquerque, USA.
Cureus. 2023 Aug 11;15(8):e43326. doi: 10.7759/cureus.43326. eCollection 2023 Aug.
Since the IARC (International Agency for Research on Cancer) announcement in 2007 indicating the possibility of night-shift work carrying carcinogenesis risk, multiple studies on a global level have been conducted to investigate the correlation between night-shift work and cancer development. Circadian rhythm disruption and decreased melatonin production have been postulated as potential contributing factors. There is also growing evidence that night-shift workers tend to adopt unhealthier lifestyles which contribute to poorer health and increase the risk of developing diseases such as cancer. No experimental study has been specifically dedicated to testing specific methods that could decrease cancer risk in night-shift workers. While there are a few studies that investigate melatonin's concurrent use with chemotherapy in cancer patients, there is yet to be seen for studies that investigate melatonin specifically as a cancer prevention method. This narrative review aims to examine current evidence of healthcare night-shift work's risk in cancer incidence, potential pathogenesis, and its significance in clinical practice.
自2007年国际癌症研究机构（IARC）宣布夜班工作可能存在致癌风险以来，全球范围内已开展了多项研究，以调查夜班工作与癌症发生之间的相关性。昼夜节律紊乱和褪黑素分泌减少被认为是潜在的促成因素。越来越多的证据表明，夜班工作者往往采取更不健康的生活方式，这会导致健康状况较差，并增加患癌症等疾病的风险。尚无专门的实验研究致力于测试可降低夜班工作者癌症风险的具体方法。虽然有一些研究调查了褪黑素在癌症患者化疗中的联合使用情况，但尚未有研究专门调查褪黑素作为一种癌症预防方法的情况。本叙述性综述旨在审视当前关于医疗保健夜班工作在癌症发病率、潜在发病机制及其在临床实践中的意义方面风险的证据。
