Dershowitz Lori B, Garcia Hassler Bueno, Perley Andrew S, Coleman Todd P, Kaltschmidt Julia A
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305 USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305 USA.
bioRxiv. 2023 Aug 6:2023.08.03.551847. doi: 10.1101/2023.08.03.551847.
Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a previously unknown pattern of spontaneous neurogenic GI motility. We further show that this motility is driven by cholinergic signaling, which may inform GI pharmacology for preterm patients.
自发神经元网络活动在中枢和外周神经回路的发育中至关重要，然而这是否是肠神经系统发育的一个特征尚未确定。通过使用胃肠道（GI）运动测定法和无偏计算分析，我们确定了一种以前未知的自发性神经源性GI运动模式。我们进一步表明，这种运动是由胆碱能信号驱动的，这可能为早产患者的胃肠道药理学提供信息。
