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环状 RNA:未来一颗极具潜力的全能型明星。

circRNA: a promising all-around star in the future.

机构信息

Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin, 300211, China.

出版信息

Epigenomics. 2023 Jun;15(12):677-685. doi: 10.2217/epi-2023-0141. Epub 2023 Aug 14.

Abstract

circRNA is a type of RNA molecule with a circular structure. From initially thinking it was useless to now discovering that it has important and complex functions, the importance of circRNA is increasingly being recognized. circRNA was first discovered as an ncRNA with a molecular sponge function. Clinically, due to its special molecular structure, researchers are generally interested in its potential as a biomarker. Recently, circRNA has been proven to have many functions other than encoding proteins. In the clinical setting, circRNA also has strong potential for application in vaccine preparation and targeted therapy. This article discusses the synthesis of circRNA, introduces its functions and discusses its future development prospects.

摘要

环状 RNA 是一种具有环状结构的 RNA 分子。环状 RNA 最初被认为是没有功能的,而现在发现它具有重要而复杂的功能,其重要性日益得到认可。环状 RNA 最初作为具有分子海绵功能的 ncRNA 被发现。临床上,由于其特殊的分子结构,研究人员普遍对其作为生物标志物的潜力感兴趣。最近,已经证明环状 RNA 除了具有编码蛋白质的功能外,还有许多其他功能。在临床环境中,环状 RNA 在疫苗制备和靶向治疗方面也具有很强的应用潜力。本文讨论了环状 RNA 的合成,介绍了其功能,并探讨了其未来的发展前景。

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