血小板衍生的细胞外囊泡在血小板输血治疗中发挥着重要作用。

Platelet-derived extracellular vesicles play an important role in platelet transfusion therapy.

机构信息

Department of Transfusion, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.

Class 2018 Medical Inspection Technology, Southwest Medical University, Luzhou, China.

出版信息

Platelets. 2023 Dec;34(1):2242708. doi: 10.1080/09537104.2023.2242708.

DOI:10.1080/09537104.2023.2242708

PMID:37578045

Abstract

Extracellular vesicles (EVs) contain the characteristics of their cell of origin and mediate cell-to-cell communication. Platelet-derived extracellular vesicles (PEVs) not only have procoagulant activity but also contain platelet-derived inflammatory factors (CD40L and mtDNA) that mediate inflammatory responses. Studies have shown that platelets are activated during storage to produce large amounts of PEVs, which may have implications for platelet transfusion therapy. Compared to platelets, PEVs have a longer storage time and greater procoagulant activity, making them an ideal alternative to platelets. This review describes the reasons and mechanisms by which PEVs may have a role in blood transfusion therapy.

摘要

细胞外囊泡（EVs）包含其起源细胞的特征，并介导细胞间通讯。血小板衍生的细胞外囊泡（PEVs）不仅具有促凝活性，而且还包含介导炎症反应的血小板衍生炎症因子（CD40L 和 mtDNA）。研究表明，血小板在储存过程中被激活会产生大量的 PEVs，这可能对血小板输血治疗有影响。与血小板相比，PEVs 的储存时间更长，促凝活性更强，因此是血小板的理想替代品。本综述描述了 PEVs 在输血治疗中可能发挥作用的原因和机制。