Department of Laboratory Medicine, Beijing Chaoyang Hospital, Beijing Center for Clinical Laboratories, The Third Clinical Medical College of Capital Medical University, Beijing, PR China.
Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai, PR China.
Platelets. 2024 Dec;35(1):2397592. doi: 10.1080/09537104.2024.2397592. Epub 2024 Sep 17.
Platelet-derived extracellular vesicles (PEVs) are released by platelets in the blood circulation, which carry a rich bio-molecular cargo influential in intercellular communications. PEVs can enter the lymph, bone marrow, and synovial fluid as nano-sized particles, while platelets cannot cross tissue barriers. Considering the advantages of PEVs such as low immunogenicity, high regulation of signal transduction, and easy obtainment, PEVs may be promising therapeutic tools for medical applications. The exceptional functional roles played by PEVs explain the recent interest in exploring new cell-free therapies that could address needs in angiogenesis, regenerative medicine, and targeted drug delivery. The review takes a critical look at the main advances of PEVs in the treatment of diseases by presenting the latest knowledge from the performed studies, in order to enhance the further translation of the PEVs research into feasible therapeutic applications.
血小板衍生的细胞外囊泡（PEVs）在血液循环中由血小板释放，携带丰富的生物分子货物，影响细胞间通讯。PEVs 可以作为纳米级颗粒进入淋巴、骨髓和滑液，而血小板不能穿过组织屏障。考虑到 PEVs 的优势，如低免疫原性、高信号转导调节和易于获取，PEVs 可能是医学应用中很有前途的治疗工具。PEVs 发挥的特殊功能作用解释了人们最近对探索新的无细胞治疗方法的兴趣，这些方法可以满足血管生成、再生医学和靶向药物输送的需求。该综述通过介绍已完成研究中的最新知识，批判性地探讨了 PEVs 在疾病治疗中的主要进展，以增强将 PEVs 研究转化为可行治疗应用的进一步转化。
