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本文引用的文献

1
Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents.抗坏血酸和其他还原剂使脱氧鸟苷在C-8位发生羟基化反应。
Nucleic Acids Res. 1984 Feb 24;12(4):2137-45. doi: 10.1093/nar/12.4.2137.
2
Detection and identification of mutagens and carcinogens as their adducts with guanosine derivatives.作为与鸟苷衍生物加合物的诱变剂和致癌物的检测与鉴定。
Nucleic Acids Res. 1984 Feb 24;12(4):2127-36. doi: 10.1093/nar/12.4.2127.
3
Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage.人和大鼠尿液中的胸腺嘧啶乙二醇和胸苷乙二醇：一种检测氧化DNA损伤的可能方法。
Proc Natl Acad Sci U S A. 1984 Sep;81(18):5633-7. doi: 10.1073/pnas.81.18.5633.
4
Hydroxymethyluracil DNA glycosylase in mammalian cells.哺乳动物细胞中的羟甲基尿嘧啶DNA糖基化酶
Proc Natl Acad Sci U S A. 1984 Jul;81(13):4003-7. doi: 10.1073/pnas.81.13.4003.
5
Formation of 8-hydroxyguanine residues in DNA by X-irradiation.
Gan. 1984 Dec;75(12):1037-9.
6
DNA damage induced by asbestos in the presence of hydrogen peroxide.过氧化氢存在时石棉诱导的DNA损伤。
Gan. 1984 Oct;75(10):841-4.
7
Hydroxylation of deoxy guanosine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion.在过氧化氢和铁离子存在的情况下，多酚和氨基酚对脱氧鸟苷的C-8位进行羟基化反应。
Gan. 1984 Jul;75(7):565-6.

加热的葡萄糖和产生活性氧的试剂使核苷和DNA中的鸟嘌呤在C-8位发生羟基化反应。

Hydroxylation of guanine in nucleosides and DNA at the C-8 position by heated glucose and oxygen radical-forming agents.

作者信息

Kasai H, Nishimura S

出版信息

Environ Health Perspect. 1986 Aug;67:111-6. doi: 10.1289/ehp.8667111.

DOI:10.1289/ehp.8667111
PMID:3757945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1474402/
Abstract

Heated glucose is mutagenic to Salmonella typhimurium TA 100 in the absence of S-9 mix. For identifying unknown mutagens in heated glucose (dry solid, 200 degrees C, 20 min), reaction with isopropylideneguanosine (IPG) was followed by isolation and characterization of the mutagen-IPG adduct. Two adducts, glyoxal-IPG and 8-hydroxy-IPG, were identified in the reaction mixture by this technique. To elucidate the mechanism of this hydroxylation reaction, we investigated the abilities of various agents to hydroxylate deoxyguanosine or guanine base in DNA. Various reducing agents, metals, asbestoses, polyphenols, aminophenols, and X-ray were effective for hydroxylation, and an oxygen radical seems to be the reactive species. For sensitive detection of 8-hydroxyguanine, a monoclonal antibody for it was prepared.

摘要

在没有S-9混合液的情况下，加热的葡萄糖对鼠伤寒沙门氏菌TA 100具有致突变性。为了鉴定加热葡萄糖（干燥固体，200℃，20分钟）中的未知诱变剂，与异丙叉鸟苷（IPG）反应后，对诱变剂-IPG加合物进行分离和表征。通过该技术在反应混合物中鉴定出两种加合物，乙二醛-IPG和8-羟基-IPG。为了阐明这种羟基化反应的机制，我们研究了各种试剂使DNA中的脱氧鸟苷或鸟嘌呤碱基羟基化的能力。各种还原剂、金属、石棉、多酚、氨基酚和X射线对羟基化有效，氧自由基似乎是反应活性物质。为了灵敏检测8-羟基鸟嘌呤，制备了针对它的单克隆抗体。