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2
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本文引用的文献

1
Chemical mutagenesis.化学诱变
Annu Rev Biochem. 1982;51:655-93. doi: 10.1146/annurev.bi.51.070182.003255.
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32P-labeling test for DNA damage.
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6126-9. doi: 10.1073/pnas.78.10.6126.
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Mutagenicity of methylglyoxal in coffee.咖啡中甲基乙二醛的致突变性。
Gan. 1982 Oct;73(5):681-3.
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The reaction of guanine derivatives with 1,2-dicarbonyl compounds.鸟嘌呤衍生物与1,2 - 二羰基化合物的反应。
Biochemistry. 1966 Sep;5(9):2799-807. doi: 10.1021/bi00873a004.
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Synthesis of 8-hydroxypurine nucleosides.8-羟基嘌呤核苷的合成。
Chem Pharm Bull (Tokyo). 1965 Sep;13(9):1140-2. doi: 10.1248/cpb.13.1140.
6
Mass spectrometry of nucleic acid components. Trimethylsilyl derivatives of nucleotides, nucleosides, and bases.核酸成分的质谱分析。核苷酸、核苷和碱基的三甲基硅烷基衍生物。
J Am Chem Soc. 1968 Jul 17;90(15):4182-4. doi: 10.1021/ja01017a062.
7
Mass spectrometry of nucleic acid components. N,O-Permethyl derivatives of nucleosides.核酸成分的质谱分析。核苷的N,O-二甲基衍生物。
J Am Chem Soc. 1973 Oct 31;95(22):7480-90. doi: 10.1021/ja00803a044.
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Fluorescent labeling of proteins. A new methodology.
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Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.用沙门氏菌/哺乳动物微粒体诱变性试验检测致癌物和诱变剂的方法。
Mutat Res. 1975 Dec;31(6):347-64. doi: 10.1016/0165-1161(75)90046-1.
10
Mutagenicity of 1,2-dicarbonyl compounds: maltol, kojic acid, diacetyl and related substances.1,2 -二羰基化合物的致突变性：麦芽酚、曲酸、双乙酰及相关物质。
Mutat Res. 1979 Aug;67(4):367-71. doi: 10.1016/0165-1218(79)90034-x.

作为与鸟苷衍生物加合物的诱变剂和致癌物的检测与鉴定。

Detection and identification of mutagens and carcinogens as their adducts with guanosine derivatives.

作者信息

Kasai H, Hayami H, Yamaizumi Z, Nishimura S

出版信息

Nucleic Acids Res. 1984 Feb 24;12(4):2127-36. doi: 10.1093/nar/12.4.2127.

DOI:10.1093/nar/12.4.2127
PMID:6701096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC318645/
Abstract

For use in screening for environmental mutagens and carcinogens, a highly fluorescent derivative of guanosine, 2'-deoxy-2'-(2",3"-dihydro-2",4"-diphenyl-2"-hydroxy-3"-oxo-1"-pyrrol yl) guanosine (FG), was synthesized. When incubated with FG in aqueous solution, mutagens form adducts that can be analyzed with an HPLC-fluorescence detector-system. By this method, mutagens such as glyoxal, methylglyoxal, 2-(2-furyl)-3-(5-nitrofuryl) acrylamide and 4-nitroquinoline-N-oxide, used as model compounds, were detected rapidly with high sensitivity. Reaction with isopropylideneguanosine (IPG), followed by isolation and characterization of the mutagen-IPG-adduct was found to be a useful method for identifying unknown mutagens in crude samples. This method was successfully applied in identification of the mutagens in heated glucose (200 degrees C, 20 min); glyoxal-IPG and 8-hydroxy-IPG were identified in the reaction mixture.

摘要

为用于环境诱变剂和致癌物的筛选，合成了鸟苷的一种高荧光衍生物，即2'-脱氧-2'-(2",3"-二氢-2",4"-二苯基-2"-羟基-3"-氧代-1"-吡咯基)鸟苷(FG)。当在水溶液中与FG一起孵育时，诱变剂会形成加合物，可通过高效液相色谱-荧光检测系统进行分析。通过这种方法，作为模型化合物的乙二醛、甲基乙二醛、2-(2-呋喃基)-3-(5-硝基呋喃基)丙烯酰胺和4-硝基喹啉-N-氧化物等诱变剂能够被快速且高灵敏度地检测出来。发现与亚异丙基鸟苷(IPG)反应，随后分离并表征诱变剂-IPG-加合物，是鉴定粗样品中未知诱变剂的一种有用方法。该方法成功应用于鉴定加热葡萄糖(200℃，20分钟)中的诱变剂；在反应混合物中鉴定出了乙二醛-IPG和8-羟基-IPG。