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[非酒精性脂肪性肝病组织学评分系统的研究进展]

[Research progress on the histological scoring system for nonalcoholic fatty liver disease].

作者信息

Li J, Ge Q Y, Song Q Y, Zhang Z H

机构信息

Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2023 Jul 20;31(7):765-769. doi: 10.3760/cma.j.cn501113-20230522-00231.

Abstract

Non-alcoholic fatty liver disease (NAFLD) has replaced chronic hepatitis B as the most common chronic liver disease in China and has now been renamed metabolic dysfunction-associated fatty liver disease (MAFLD). The Brunt, the American NASH Clinical Research Network (NASH-CRN), the European Steatosis, Activity, and Fibrosis/Fatty Liver Inhibition of Progression (SAF/FLIP), and the Pediatric NAFLD are currently the four semi-quantitative grading systems for histological evaluation. This paper reviews these four scoring systems for the clinical selection of appropriate systems for diagnosis and prognosis assessment. This article is a review, and in order to coordinate the evaluation criteria of various scoring systems, the old name "NAFLD" is used.

摘要

非酒精性脂肪性肝病(NAFLD)已取代慢性乙型肝炎,成为中国最常见的慢性肝病,目前已更名为代谢功能障碍相关脂肪性肝病(MAFLD)。布伦特(Brunt)、美国非酒精性脂肪性肝炎临床研究网络(NASH-CRN)、欧洲脂肪变性、活动度和纤维化/脂肪肝进展抑制(SAF/FLIP)以及儿童非酒精性脂肪性肝病目前是组织学评估的四种半定量分级系统。本文综述这四种评分系统,以便临床选择合适的系统进行诊断和预后评估。本文为综述,为协调各种评分系统的评估标准,使用旧称“NAFLD”。

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