在健康和疾病中平衡溶酶体丰度。
Balancing lysosome abundance in health and disease.
机构信息
Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Huddinge, Sweden.
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
出版信息
Nat Cell Biol. 2023 Sep;25(9):1254-1264. doi: 10.1038/s41556-023-01197-7. Epub 2023 Aug 14.
Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in lysosome abundance are implicated in human diseases. Here we outline the mechanisms of lysosome biogenesis and turnover, and discuss how changes in the lysosome pool impact physiological and pathophysiological processes.
溶酶体是一种分解代谢细胞器，可调控多种细胞进程，包括大分子降解、营养信号转导和离子动态平衡。溶酶体丰度的异常改变与人类疾病有关。在此，我们概述了溶酶体发生和周转的机制，并讨论了溶酶体池的变化如何影响生理和病理生理过程。
Zotero 插件