通过标记溶酶体来研究细胞器的异质性。
Painting lysosomes to study organelle heterogeneity.
作者信息
Chen Di, Gutierrez Maximiliano G
机构信息
Host Pathogen Interactions in Tuberculosis laboratory, The Francis Crick Institute, London, UK.
出版信息
J Cell Biol. 2025 Jan 6;224(1). doi: 10.1083/jcb.202412011. Epub 2024 Dec 16.
Abstract
Like other organelles, the heterogeneity of lysosomes within a single cell has been challenging to capture and study in detail. In this issue, Chen and Gutierrez discuss new work that tackles this question using DNA-PAINT imaging, from Lakadamyali and colleagues (https://doi.org/10.1083/jcb.202403116).
摘要
与其他细胞器一样，单个细胞内溶酶体的异质性一直难以详细捕捉和研究。在本期杂志中，Chen和Gutierrez讨论了Lakadamyali及其同事利用DNA-PAINT成像技术解决这一问题的新研究（https://doi.org/10.1083/jcb.202403116）。
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本文引用的文献
1
Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging.通过多重 DNA-PAINT 成像显示晚期内体/溶酶体的异质性。
J Cell Biol. 2025 Jan 6;224(1). doi: 10.1083/jcb.202403116. Epub 2024 Nov 1.
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One size does not fit all: Lysosomes exist in biochemically and functionally distinct states.一概而论是不对的：溶酶体存在于生化和功能上明显不同的状态。
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Balancing lysosome abundance in health and disease.在健康和疾病中平衡溶酶体丰度。
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Chemically Resolving Lysosome Populations in Live Cells.在活细胞中化学解析溶酶体群体
Trends Biochem Sci. 2020 Apr;45(4):365-366. doi: 10.1016/j.tibs.2019.12.006. Epub 2020 Feb 11.
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Lysosomes as dynamic regulators of cell and organismal homeostasis.溶酶体作为细胞和整体内稳态的动态调节剂。
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